CAJ | 학술논문

目的探讨新一代质子泵抑制剂埃索美拉唑对反流性食管炎(RE)的临床疗效.方法将80例经内窥镜证实的RE患者随机分为两组.治疗组40例,给予埃索美拉唑20 mg/次,每日2次;对照组40例,给予法莫替丁20 mg/次,每日2次.疗程均为4周,两组同时加用促动力剂莫沙必利5 mg/次,每日3次.治疗结束后,记录烧心、反酸和胸骨后灼痛症状缓解率和胃镜复查总有效率.结果:症状缓解的总有效率治疗组为92.5%,对照组为62.5%,两组差异有统计学意义(P＜0.05);胃镜复查总有效率治疗组为82.5%,对照组为55.0%,两组差异有统计学意义(P＜0.05).结论埃索美拉唑治疗反流性食管炎安全有效.
목적 탐토신일대질자빙억제제애색미랍서대반류성식관염(RE)적림상료효.방법 장80례경내규경증실적RE환자수궤분위량조.치료조40례,급여애색미랍서20 mg/차,매일2차;대조조40례,급여법막체정20 mg/차,매일2차.료정균위4주,량조동시가용촉동력제막사필리5 mg/차,매일3차.치료결속후,기록소심、반산화흉골후작통증상완해솔화위경복사총유효솔.결과:증상완해적총유효솔치료조위92.5%,대조조위62.5%,량조차이유통계학의의(P＜0.05);위경복사총유효솔치료조위82.5%,대조조위55.0%,량조차이유통계학의의(P＜0.05).결론 애색미랍서치료반류성식관염안전유효.
Objective To investigate the therapeutic effect of esomeprazole,a new type 0f proton pump inhibitor(PPI),on patients with reflux esophagitis(RE).Methods 80 cases with RE diagnosed by endoscope were randomly divided into treatmeat group(n=40)and control group(n=40).The treatmeat group was treated with esomeprazole 20 mg bid,compared with the control group famotidine 20mg bid.The two courses of treatment both persisted for four weeks and included mosapride 5mg tid.At the end of therapy,the rate of relief of heartburn,acid reflux and substernal burning symptom,and the total effective rate confirmed by endoscope were recorded.ResuIts The clinical symptoms relief rates were 92.5%in the treatment and 62.5%in the control group raspectively and had obviously statistical difference(P＜0.05).The total effective rate was confirmed by endoscope were 82.5%and 55.0%respectively in two groups(P＜0.05).Conclusion Esomeprazole is a type of effective drug for patients with RE.