国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2011年
5期
303-305
,共3页
肝肾综合征%肝硬化%前列腺素E1脂微球%大黄
肝腎綜閤徵%肝硬化%前列腺素E1脂微毬%大黃
간신종합정%간경화%전렬선소E1지미구%대황
Hepatorenal syndrome%Liver cirrhosis%Lipoprostaglandin E1%Chinese rhubarb
目的 观察前列腺素E1脂微球联合大黄治疗肝硬化失代偿期肝肾综合征的疗效.方法 26例肝肾综合征患者随机分为2组,在综合治疗的基础上,对照组22例患者给予多巴胺联合大剂量呋塞米,治疗组24例使用前列腺素E1脂微球联合大黄.观察两组疗效、尿量、尿素氮、肌酐、肝功能、血氨及治疗后转归情况.结果 治疗组总有效率为85.71％,显著优于对照组的41.67％( x2=0.02,P＜0.01).与治疗前比较,疗程结束时治疗组尿量显著增加(t=8.98,P＜0.01),尿素氮、血肌酐明显降低(t=8.53、17.22,P＜0.01),ALT和TBil有不同程度的改善、血氨下降(t=15.99、4.56、9.22,P＜0.01)；而对照组上述指标均无明显改善.治疗后两组肌酐、尿素氮、ALT、TBil及血氨比较差异均有统计学意义(t=10.72、8.96、5.86、2.35、9.01,P＜ 0.05).结论 前列腺素E1脂微球可改善血流动力学变化,增加尿量,而中药大黄可减少肠道毒素吸收,减轻肝肾损害,两者联用有助于肝肾功能的恢复.
目的 觀察前列腺素E1脂微毬聯閤大黃治療肝硬化失代償期肝腎綜閤徵的療效.方法 26例肝腎綜閤徵患者隨機分為2組,在綜閤治療的基礎上,對照組22例患者給予多巴胺聯閤大劑量呋塞米,治療組24例使用前列腺素E1脂微毬聯閤大黃.觀察兩組療效、尿量、尿素氮、肌酐、肝功能、血氨及治療後轉歸情況.結果 治療組總有效率為85.71％,顯著優于對照組的41.67％( x2=0.02,P＜0.01).與治療前比較,療程結束時治療組尿量顯著增加(t=8.98,P＜0.01),尿素氮、血肌酐明顯降低(t=8.53、17.22,P＜0.01),ALT和TBil有不同程度的改善、血氨下降(t=15.99、4.56、9.22,P＜0.01)；而對照組上述指標均無明顯改善.治療後兩組肌酐、尿素氮、ALT、TBil及血氨比較差異均有統計學意義(t=10.72、8.96、5.86、2.35、9.01,P＜ 0.05).結論 前列腺素E1脂微毬可改善血流動力學變化,增加尿量,而中藥大黃可減少腸道毒素吸收,減輕肝腎損害,兩者聯用有助于肝腎功能的恢複.
목적 관찰전렬선소E1지미구연합대황치료간경화실대상기간신종합정적료효.방법 26례간신종합정환자수궤분위2조,재종합치료적기출상,대조조22례환자급여다파알연합대제량부새미,치료조24례사용전렬선소E1지미구연합대황.관찰량조료효、뇨량、뇨소담、기항、간공능、혈안급치료후전귀정황.결과 치료조총유효솔위85.71％,현저우우대조조적41.67％( x2=0.02,P＜0.01).여치료전비교,료정결속시치료조뇨량현저증가(t=8.98,P＜0.01),뇨소담、혈기항명현강저(t=8.53、17.22,P＜0.01),ALT화TBil유불동정도적개선、혈안하강(t=15.99、4.56、9.22,P＜0.01)；이대조조상술지표균무명현개선.치료후량조기항、뇨소담、ALT、TBil급혈안비교차이균유통계학의의(t=10.72、8.96、5.86、2.35、9.01,P＜ 0.05).결론 전렬선소E1지미구가개선혈류동역학변화,증가뇨량,이중약대황가감소장도독소흡수,감경간신손해,량자련용유조우간신공능적회복.
Objective To observe the effect of lipoprostaglandin E1 (lipo-PegE1) with Chinese rhubarb in treatment of patients with hepatorenal syndrome.Methods 26 hepatorenal syndrome patients were divided into two groups randomly.Based on the comprehensive treatment,treatment group(24 cases)were given lipo-PegE1 with Chinese rhubarb,while control group(22 cases)were given dopamine and large-dose of furosemide.The clinical effect,total urine output,BUN,creatinine,liver function,blood ammonia and prognosis were observed.Results The total effective rate was 85.71％ in treatment group,and were significantly better than the rate(41.67％ )in control group( x2 =0.02,P ＜0.01 ).In treatment group,urine output were significantly increased after the treatment ( t =8.98,P ＜ 0.01).BUN and serum creatinine were significantly lower( t =8.53,17.22,P ＜ 0.01),ALT and TBil improved in different degree and blood ammonia decreased ( t =15.99,4.56,9.22,P ＜ 0.01 ) ; while in control group,these parameters had no significant improvement.After treatment,there were significant differences in creatinine,BUN,ALT,TBil and ammonia between the two groups( t =10.72,8.96,5.86,2.35,9.01,P ＜ 0.05).Conclusions Lipo-PegE1 can change hemodynamics and increase the urine output,while Chinese rhubarb can reduce endotoxin in patients with hepatorenal syndrome,so lipo-PegEl combine with Chinese rhubarb can get enhanced results in the treatment of hepatorenal syndrome.
