CAJ | 학술논문

目的探讨高血压病患者颈动脉斑块与血压变异以及与心血管危险因素的关系.方法对2009年4月至2010年6月在高血压科住院患者临床资料进行回顾性分析,其中408例患者颈动脉B超检查及其他临床资料完善,并且均做动态血压监测.结果 (1)颈动脉斑块检出率为55.3%,男女性别间差异无统计学意义,但随年龄增大阳性率显著增加.(2)颈动脉斑块与高血压病病程、空腹血糖、总胆固醇、低密度脂蛋白胆固醇相关.(3)24 h动态血压与颈动脉斑块:随着收缩压变异系数增大,颈动脉斑块发生率增加(P=0.001),舒张压变异系数与颈动脉斑块发生率无相关性(P=0.644),平均收缩压越大,发生率越高(P=0.002).(4)多元回归提示,颈动脉斑块与24 h平均收缩压、24 h收缩压变异系数相关(P<0.05).结论在高血压病患者中,颈动脉粥样硬化与血压变异系数、尤其是收缩压变异系数独立相关.
목적 탐토고혈압병환자경동맥반괴여혈압변이이급여심혈관위험인소적관계.방법 대2009년4월지2010년6월재고혈압과주원환자림상자료진행회고성분석,기중408례환자경동맥B초검사급기타림상자료완선,병차균주동태혈압감측.결과 (1)경동맥반괴검출솔위55.3%,남녀성별간차이무통계학의의,단수년령증대양성솔현저증가.(2)경동맥반괴여고혈압병병정、공복혈당、총담고순、저밀도지단백담고순상관.(3)24 h동태혈압여경동맥반괴:수착수축압변이계수증대,경동맥반괴발생솔증가(P=0.001),서장압변이계수여경동맥반괴발생솔무상관성(P=0.644),평균수축압월대,발생솔월고(P=0.002).(4)다원회귀제시,경동맥반괴여24 h평균수축압、24 h수축압변이계수상관(P<0.05).결론 재고혈압병환자중,경동맥죽양경화여혈압변이계수、우기시수축압변이계수독립상관.
Objective To investigate the relationship of carotid artery plaque and blood pressure variation and cardiovascular risk factors.Methods We retrospectively analyzed clinical data of in-patients treated in the department of hypertension between April 2009 and June 2010.Information on carotid ultrasonography and other clinical date were obtained from 408 patients.All patients were monitored by ambulatory blood pressure.Results (1) Carotid artery determined in plaque was 55.3%,there was no differences between men and women.However,the carotid artery plague was associated positively with age.Increased age was associated with a significantly increased positive rate.(2) Cardiovascular risk factors and carotid artery plaque: carotid artery plaque was associated with duration of disease, fasting blood sugar, total cholesterol, and low density lipoprotein-cholesterol.(3) 24 h ambulatory blood pressure and carotid artery plaque: the prevalence of carotid artery plaque increased with increasing coefficient of systolic variation (P=0.001).There was no correlation between the coefficient of diastolic variation and the prevalence (P=0.644).(4) Multivariate regression analysis indicated that carotid artery plaque was associated with duration of hypertension, 24 h mean systolic blood pressure, and coefficient of variation of 24 h blood pressure (P<0.05 ).Conclusion Carotid atherosclerosis is independently associated with coefficient of variation of blood pressure, especially with coefficient of variation of systolic blood pressure.