CAJ | 학술논문

为探讨高温、香烟及其联合作用对大鼠胚胎神经系统发育的影响，用高温、香烟及其联合作用处理孕8～11天的大鼠，孕20天后按致畸实验方法观察胚胎神经系统的发育(包括头长、神经管末闭、体位异常和脑部形态异常)。结果表明头长、神经管未闭、体位异常和脑部形态异常发生率均与高温温度、香烟剂量及香烟持续时间呈正比关系(P＜0.05)；并与损害时间发生于胚胎发育的时段有密切关系，孕9～10日大鼠神经系统异常发生率明显高于其它时段(P<0.01)。研究结果还显示高温与香烟联合作用其胚胎神经系统异常发生率明显高于高温或香烟的作用(P＜0.01)。提示高温、香烟及其联合作用明显损害孕9～10日的胚胎神经系统。
위탐토고온、향연급기연합작용대대서배태신경계통발육적영향，용고온、향연급기연합작용처리잉8～11천적대서，잉20천후안치기실험방법관찰배태신경계통적발육(포괄두장、신경관말폐、체위이상화뇌부형태이상)。결과표명두장、신경관미폐、체위이상화뇌부형태이상발생솔균여고온온도、향연제량급향연지속시간정정비관계(P＜0.05)；병여손해시간발생우배태발육적시단유밀절관계，잉9～10일대서신경계통이상발생솔명현고우기타시단(P<0.01)。연구결과환현시고온여향연연합작용기배태신경계통이상발생솔명현고우고온혹향연적작용(P＜0.01)。제시고온、향연급기연합작용명현손해잉9～10일적배태신경계통。
In order to explore the effect of high temperature or cigarettesmoke and their combined effect on the development of nervous system in early rat embryos,pregnant rats at the 8～11th day of gestation were exposed to high temperature and water soluble substances of cigarette smoke.All indexed of embryonic nervous system development were determined with experimental treat logical methods.The results showed that following the increase of temperature or cigarette smoke exposure all indexes correlated with embryonic nervous system development and morphological differentiation were changed, with an apparent dose-effect relationship (P<0.01).The changes were related to specific phase of embryonic development. The results showed also that the nervous system development and morphological differentiation induced by both high temperature and cigarette smoke were higher than that by any single factor.