CAJ | 학술논문

目的探讨β-连环素与E-钙粘素在肝癌中的表达及与临床病理学的意义.方法采用S-P免疫组化法检测β-连环素及E-钙粘素在72例肝癌的表达.结果在肝癌中β-连环素(76.4%)和E-钙粘素异常表达(61.1%)均明显高于癌周组织与肝硬化(P＜0.001).β-连环素或E-钙粘素异常表达在肝癌中分化呈明显相关(P＜0.001).E-钙粘素异常表达在门静脉有无癌栓中呈明显相关(P＜0.01).结论β-连环素与E-钙粘素异常表达可能参与肝癌发生、发展,并与肝癌的临床生物特性有一定关系.
목적탐토β-련배소여E-개점소재간암중적표체급여림상병이학적의의.방법채용S-P면역조화법검측β-련배소급E-개점소재72례간암적표체.결과재간암중β-련배소(76.4%)화E-개점소이상표체(61.1%)균명현고우암주조직여간경화(P＜0.001).β-련배소혹E-개점소이상표체재간암중분화정명현상관(P＜0.001).E-개점소이상표체재문정맥유무암전중정명현상관(P＜0.01).결론β-련배소여E-개점소이상표체가능삼여간암발생、발전,병여간암적림상생물특성유일정관계.
[Objective] To investigate the expression of β-catenin and E-cadherin and the clinicaopathological significance in hepatic cancer. [Methods] β-catenin and E-cadherin expressions in 72 patients with hepatic cancer were detected byimmunohistochemical method. [Results] The abnormal expression β-catenin(76.4%) and E-cadherin(61.1%) in hepatic cancer was significantly higher than that in paracancer and liver cirrhosis (P ＜0.001). The abnormal expression of β-catenin and E-cadherin showed significant relationship with differentiation grade (P ＜0.001). The abnormal expression of E-cadherin significantly was related with portal vein embolus or not (P ＜0.01).[ Conclusions ] The β-catenin and E-cadherin may participate in the process of development, progression in hepatic cancer. The abdominal expression of β-catenin and E-cadherin is related with biological characteristic of hepatic cancer.