国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2012年
5期
372-377
,共6页
过氧化物酶体增生物激活受体γ%噻唑烷二酮类%噻二唑类%脑缺血%神经保护药
過氧化物酶體增生物激活受體γ%噻唑烷二酮類%噻二唑類%腦缺血%神經保護藥
과양화물매체증생물격활수체γ%새서완이동류%새이서류%뇌결혈%신경보호약
PPAR γ%Thiazolidinediones%Thiadiazoles%Brain Ischemia%Neuroprotective Agents
噻唑烷二酮类物质为过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)的合成配体.PPARγ对多种类型组织均有一定的保护作用,研究涉及的领域包括糖及脂类代谢、癌症、动脉粥样硬化等.目前,噻唑烷二酮类物质在中枢神经系统疾病中的作用备受关注,如脑梗死、多发性硬化、阿尔茨海默病等.文章综述了脑缺血后PPARγ配体噻唑烷二酮类对抑制神经胶质细胞增殖、促进血管生成以及对抗神经元凋亡的作用.
噻唑烷二酮類物質為過氧化物酶體增殖物激活受體γ(peroxisome proliferator-activated receptorγ,PPARγ)的閤成配體.PPARγ對多種類型組織均有一定的保護作用,研究涉及的領域包括糖及脂類代謝、癌癥、動脈粥樣硬化等.目前,噻唑烷二酮類物質在中樞神經繫統疾病中的作用備受關註,如腦梗死、多髮性硬化、阿爾茨海默病等.文章綜述瞭腦缺血後PPARγ配體噻唑烷二酮類對抑製神經膠質細胞增殖、促進血管生成以及對抗神經元凋亡的作用.
새서완이동류물질위과양화물매체증식물격활수체γ(peroxisome proliferator-activated receptorγ,PPARγ)적합성배체.PPARγ대다충류형조직균유일정적보호작용,연구섭급적영역포괄당급지류대사、암증、동맥죽양경화등.목전,새서완이동류물질재중추신경계통질병중적작용비수관주,여뇌경사、다발성경화、아이자해묵병등.문장종술료뇌결혈후PPARγ배체새서완이동류대억제신경효질세포증식、촉진혈관생성이급대항신경원조망적작용.
Thiazolidinodiones are a synthetic ligand of peroxisome proliferator-activated receptor γ(PPARγ).PPARγhas certain protective effects for several types of tissues.The research covers the areas of glucose,lipid metabolism,cancer and atherosclerosis,etc.At present,the roles of thiazolidinediones in central nervous system diseases have received much attention,such as cerebral infarction,multiple sclerosis,and Alzheimer's disease.This article reviews the effects of PPARγ ligand thiazolidinediones on inhibiting the proliferation of glial cells,promoting angiogenesis,and antagonizing neuronal apoptosis after cerebral ischemia.
