中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
6期
810-811
,共2页
鼻炎,变应性,常年性%趋化因子,嗜酸细胞%糠酸莫米松%儿童
鼻炎,變應性,常年性%趨化因子,嗜痠細胞%糠痠莫米鬆%兒童
비염,변응성,상년성%추화인자,기산세포%강산막미송%인동
Rhinitis,allergic,perennial%Chemotactic factor,eosinophil%Mometasone%Child
目的 观察糠酸莫米松鼻喷雾剂对变应性鼻炎(AR)患儿血清嗜酸性粒细胞趋化因子( eotaxin)水平的影响.方法 30例AR患儿作为观察组,给予糠酸莫米松鼻喷雾剂治疗,使用ELISA法分别测定治疗前后血清eotaxin含量,同时与健康儿童(对照组)进行比较.结果 观察组治疗前症状和体征分数为(9.4±2.3)分,治疗后为(3.1±1.8)分,治疗前后差异有统计学意义(t =2.148,P＜0.05)；治疗效果:显效19例(63.3％),有效9例(30.0％),无效2例(6.7％).观察组治疗前eotaxin水平(221.41±137.96)ng/L,显著高于对照组的(128.71±60.73)ng/L(t =-2.721,P＜0.05)；观察组治疗后血清eotaxin水平(115.50±52.71)ng/L,显著低于治疗前(t =-3.661,P＜0.05).观察组未发生严重不良反应.结论 糠酸莫米松鼻喷剂治疗AR可以抑制变应性炎症,降低趋化因子eotaxin的水平.
目的 觀察糠痠莫米鬆鼻噴霧劑對變應性鼻炎(AR)患兒血清嗜痠性粒細胞趨化因子( eotaxin)水平的影響.方法 30例AR患兒作為觀察組,給予糠痠莫米鬆鼻噴霧劑治療,使用ELISA法分彆測定治療前後血清eotaxin含量,同時與健康兒童(對照組)進行比較.結果 觀察組治療前癥狀和體徵分數為(9.4±2.3)分,治療後為(3.1±1.8)分,治療前後差異有統計學意義(t =2.148,P＜0.05)；治療效果:顯效19例(63.3％),有效9例(30.0％),無效2例(6.7％).觀察組治療前eotaxin水平(221.41±137.96)ng/L,顯著高于對照組的(128.71±60.73)ng/L(t =-2.721,P＜0.05)；觀察組治療後血清eotaxin水平(115.50±52.71)ng/L,顯著低于治療前(t =-3.661,P＜0.05).觀察組未髮生嚴重不良反應.結論 糠痠莫米鬆鼻噴劑治療AR可以抑製變應性炎癥,降低趨化因子eotaxin的水平.
목적 관찰강산막미송비분무제대변응성비염(AR)환인혈청기산성립세포추화인자( eotaxin)수평적영향.방법 30례AR환인작위관찰조,급여강산막미송비분무제치료,사용ELISA법분별측정치료전후혈청eotaxin함량,동시여건강인동(대조조)진행비교.결과 관찰조치료전증상화체정분수위(9.4±2.3)분,치료후위(3.1±1.8)분,치료전후차이유통계학의의(t =2.148,P＜0.05)；치료효과:현효19례(63.3％),유효9례(30.0％),무효2례(6.7％).관찰조치료전eotaxin수평(221.41±137.96)ng/L,현저고우대조조적(128.71±60.73)ng/L(t =-2.721,P＜0.05)；관찰조치료후혈청eotaxin수평(115.50±52.71)ng/L,현저저우치료전(t =-3.661,P＜0.05).관찰조미발생엄중불량반응.결론 강산막미송비분제치료AR가이억제변응성염증,강저추화인자eotaxin적수평.
Objective To observe the effect of mometasone furoate on serous eotaxin in children with allergic rhinitis.Methods The observation group included 30 cases who got allergic rhinitis and treated by mometasone furoate.The level of eotaxin before and after treatment was detected by ELISA,and was compared with normal children in control group.Results Before treatment,the signs scores of observation group was (9.4 ± 2.3 ),and after treatment was(3.1 ± 1.8),the difference was statistically significant(t =2.148,P ＜0.05).The treatment effect contained 19 cases(63.3％ ) 9 cases(30.0％ ) effective and 2 cases(6.7％ ) ineffective.Before treatment,the level of eotaxin in observation group was remarkably higher than control group [ (221.41 ± 137.96 ) ng/L vs ( 128.71 ± 60.73 ) ng/L,t =- 2.721,P ＜ 0.05 ],after treatment,symptom and sign was mitigated and eotaxin level was remarkably lower than before treatment[ ( 115.50 ± 52.71 ) ng/L vs (221.41 ± 137.96 ) ng/L,t =- 3.661,P ＜ 0.05 ].There was no serious adverse reaction in observation group.Conclusion Treated allergic rhinitis by corticosteroids could inhibit the allergic inflammation and down-regulate the eotaxin level.
