CAJ | 학술논문

目的研究腹型肥胖对初发2型糖尿病胰岛β细胞早期分泌相的影响.方法将86例初诊2型糖尿病患者按照腰臀比0.85(男)或0.80(女)分为腹型肥胖组(52例)和非腹型肥胖组(34例).观察这些患者的血糖、血脂等代谢指标以及胰岛素抵抗指数(HOMA-IR)、早期胰岛素分泌指数(HOMA-IS)、快速相胰岛素分泌指数(ISF-Arg)等胰岛素分泌指标.结果非腹型肥胖组糖化血红蛋白(9.1±2.7)%,高于腹型肥胖组的(8.5±2.4)%,2组SBP、TG、HDL-C相比,差异有统计学意义(P＜0.01)[非腹型肥胖组分别为(126.2±18.1)mm Hg(1 mm Hg=0.133 kPa)、(1.49±0.78)mmol/L、(1.3±0.3)mmol/L,腹型肥胖组分别为(134.2±17.4)mm Hg、(2.24±1.01)mmol/L、(1.1±0.4)mmol/L].经校正,非腹型肥胖组患者的ISF-Arg、HOMA-IS明显低于腹型肥胖组[(2.88±0.12)vs(3.75±0.10);(2.86±0.13)vs(3.65±0.01);P＜0.01].结论以腰臀比作为腹型肥胖指标有助于初步判断患者胰岛β细胞早期分泌.
목적 연구복형비반대초발2형당뇨병이도β세포조기분비상적영향.방법 장86례초진2형당뇨병환자안조요둔비0.85(남)혹0.80(녀)분위복형비반조(52례)화비복형비반조(34례).관찰저사환자적혈당、혈지등대사지표이급이도소저항지수(HOMA-IR)、조기이도소분비지수(HOMA-IS)、쾌속상이도소분비지수(ISF-Arg)등이도소분비지표.결과 비복형비반조당화혈홍단백(9.1±2.7)%,고우복형비반조적(8.5±2.4)%,2조SBP、TG、HDL-C상비,차이유통계학의의(P＜0.01)[비복형비반조분별위(126.2±18.1)mm Hg(1 mm Hg=0.133 kPa)、(1.49±0.78)mmol/L、(1.3±0.3)mmol/L,복형비반조분별위(134.2±17.4)mm Hg、(2.24±1.01)mmol/L、(1.1±0.4)mmol/L].경교정,비복형비반조환자적ISF-Arg、HOMA-IS명현저우복형비반조[(2.88±0.12)vs(3.75±0.10);(2.86±0.13)vs(3.65±0.01);P＜0.01].결론 이요둔비작위복형비반지표유조우초보판단환자이도β세포조기분비.
Objective To study the impact of central obesity on insulin resistance and the function of pancreaticβcells in newly diagnosed Type 2 diabetes. Methods Eighty-six type 2 diabetes mellitus (T2DM) patients were divided into 2 groups according to their waist to hip ratio. Metabolic parameters and Insulin resistance and the function of pancreatic β-cells were compared. Insulin resistance were calculated by HOMA-IR and the function of pancreatic β-cells were detected by HOMA-βand ISF-Arg. Results HOMA-IR index, HOMA-IS and ISF-Arg in WHR ≥0.85 (male) or 0.80 (female) group were significantly higher than that of WHR ＜ 0. 85 (male) or 0. 80 (female) group ( P ＜ 0. 01 ), whereas WHR ＜ 0. 85 (male) or 0. 8 ( female ) group had significantly higher fasting sugar levels and HbA1c and favorable lipid profile (P ＜ 0.05 ). Conclusion WHR is an useful parameter in roughly judging the function of β-cell and insulin resistance.