中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2010年
3期
324-328
,共5页
司徒明镜%张毅%李涛%高欣%张晓薇%方慧%黄颐
司徒明鏡%張毅%李濤%高訢%張曉薇%方慧%黃頤
사도명경%장의%리도%고흔%장효미%방혜%황이
双生子研究%亲社会行为%定量遗传分析
雙生子研究%親社會行為%定量遺傳分析
쌍생자연구%친사회행위%정량유전분석
twin study%prosocial behavior%quantitative genetic analysis
目的 应用双生子设计的定量遗传分析方法探讨遗传因素与环境因素对于儿童亲社会行为的影响.方法 使用长处与困难问卷(strengths and difficulties questionnaire,SDQ)家长版本调查了147对成都地区6~16岁双生子的亲社会行为,使用SPSS13.0统计软件、Mx软件进行描述性统计分析、差异性分析、相关分析及遗传分析.结果 (1)除<11岁组外,女性亲社会因子得分显著高于男性(P3<0.05);(2)共享环境因素对儿童亲社会行为的贡献为0.48(95%CI:0.09~0.73),遗传因素的贡献为0.27(95%CI:0~0.66),个体特异性环境因素的贡献为0.25(95%CI:0.18~0.35);(3)女性、家庭实际及理想的亲密度和适应性越好者亲社会行为越好(r:0.17~0.29),而存在孕产期异常情况者、家长管教态度越不一致者亲社会行为越不良(r:-0.16~-0.28).结论 遗传因素和环境因素对儿童的亲社会行为均有影响,年龄和性别与儿童亲社会行为的遗传度相关,影响儿童亲社会行为的环境因素包括家庭功能和教养环境.
目的 應用雙生子設計的定量遺傳分析方法探討遺傳因素與環境因素對于兒童親社會行為的影響.方法 使用長處與睏難問捲(strengths and difficulties questionnaire,SDQ)傢長版本調查瞭147對成都地區6~16歲雙生子的親社會行為,使用SPSS13.0統計軟件、Mx軟件進行描述性統計分析、差異性分析、相關分析及遺傳分析.結果 (1)除<11歲組外,女性親社會因子得分顯著高于男性(P3<0.05);(2)共享環境因素對兒童親社會行為的貢獻為0.48(95%CI:0.09~0.73),遺傳因素的貢獻為0.27(95%CI:0~0.66),箇體特異性環境因素的貢獻為0.25(95%CI:0.18~0.35);(3)女性、傢庭實際及理想的親密度和適應性越好者親社會行為越好(r:0.17~0.29),而存在孕產期異常情況者、傢長管教態度越不一緻者親社會行為越不良(r:-0.16~-0.28).結論 遺傳因素和環境因素對兒童的親社會行為均有影響,年齡和性彆與兒童親社會行為的遺傳度相關,影響兒童親社會行為的環境因素包括傢庭功能和教養環境.
목적 응용쌍생자설계적정량유전분석방법탐토유전인소여배경인소대우인동친사회행위적영향.방법 사용장처여곤난문권(strengths and difficulties questionnaire,SDQ)가장판본조사료147대성도지구6~16세쌍생자적친사회행위,사용SPSS13.0통계연건、Mx연건진행묘술성통계분석、차이성분석、상관분석급유전분석.결과 (1)제<11세조외,녀성친사회인자득분현저고우남성(P3<0.05);(2)공향배경인소대인동친사회행위적공헌위0.48(95%CI:0.09~0.73),유전인소적공헌위0.27(95%CI:0~0.66),개체특이성배경인소적공헌위0.25(95%CI:0.18~0.35);(3)녀성、가정실제급이상적친밀도화괄응성월호자친사회행위월호(r:0.17~0.29),이존재잉산기이상정황자、가장관교태도월불일치자친사회행위월불량(r:-0.16~-0.28).결론 유전인소화배경인소대인동적친사회행위균유영향,년령화성별여인동친사회행위적유전도상관,영향인동친사회행위적배경인소포괄가정공능화교양배경.
Objective Using quantitative genetic analysis of twin study design to explore the impact of genetic and environmental factors on the prosocial behaviors of children. Methods One hundred and forty seven twin pairs from Chengdu area aged 6-16 were studied using parental information of Strengths and Difficulties Questionnaire (SDQ). SPSS13. 0 and Mx software were used to analyze data, including nonparametric test, Pearson correlation, genetic analyses, etc. Results (1) Female children score higher than males on their prosocial behavior (Ps<0. 05), except the <11 age group; (2) Shared environmental factors were the most important for children's prosocial behaviors(C=0. 48,95%CI:0. 09-0. 73),then the genetic factors (A = 0. 27,95%CI:0-0. 66) and the unshared environmental factors(E=0. 25,95%CI:0. 18-0. 35) ; (3) Female and those who scored higher on their fact/ideal family adaptability and cohesion scored higher in their prosocial behaviors (r:0. 17-0. 29). On the contrary, those who had extreme conditions during pregnancy/perinatal period or whose caretaker had discordant opinions on parenting scored lower (r: -0. 16-0. 28). Conclusion Children's prosocial behaviors were influenced by genetic and environmental factors including family function and parenting environment, and genetic impact differs in different age and sex.