中国地方病学杂志
中國地方病學雜誌
중국지방병학잡지
CHINESE JOURNAL OF ENDEMIOLOGY
2012年
2期
156-158
,共3页
刘庆斌%刘晓波%王树君%刘学慧%于冰%姜志立%王在君%周明仁%璋显坤%田淑彩
劉慶斌%劉曉波%王樹君%劉學慧%于冰%薑誌立%王在君%週明仁%璋顯坤%田淑綵
류경빈%류효파%왕수군%류학혜%우빙%강지립%왕재군%주명인%장현곤%전숙채
氟化物中毒%干预性研究%结果评价
氟化物中毒%榦預性研究%結果評價
불화물중독%간예성연구%결과평개
Fluoride poisoning%Intervention studies%Outcome assessment
目的 观察不同含氟量低氟青砖茶预防饮茶型氟中毒效果.方法 选择内蒙古克什克腾旗饮茶型氟中毒病区达来诺日镇罕达罕、哈达英格嘎查作为预防试验点,分别投放含氟量为(204.5±10.2)、(308.2±15.4)mg/kg的低氟青砖茶12个月.观察指标包括预防试验点病情[采用Dean法检测20 ～ 70岁成人氟斑牙,临床及Ⅹ线法检测氟骨症,并根据《地方性氟骨症诊断标准》(WS 192-2008)进行诊断]和预防试验前后砖茶、饮水、奶茶、成人尿含氟量(采用氟离子选择电极法),并计算经奶茶的摄氟量.结果 预防试验点罕达罕嘎查成人氟斑牙检出率为68.89％(62/90),临床氟骨症检出率为55.32％(52/94),Ⅹ线氟骨症检出率为65.17％(58/89);哈达英格嘎查成人氟斑牙检出率为54.84％(51/93),临床氟骨症检出率为65.69％(67/102),Ⅹ线氟骨症检出率为61.36％(54/88).罕达罕、哈达英格嘎查预防试验前砖茶含氟量分别为(831.4±138.9)、(864.3±134.6)mg/kg,饮水含氟量分别为(0.27±0.05)、(0.54±0.24)mg/L,奶茶含氟量分别为(2.16±1.12)、(2.82±1.38)mg/L,成人尿含氟量分别为(2.78±1.57)、(2.96±1.80)mg/L,经奶茶摄氟量分别为(8.12±5.84)、(6.42±5.04)mg/d;而预防试验后砖茶含氟量分别为(204.5±10.2)、(308.2±15.4)mg/kg,饮水含氟量分别为(0.34±0.11)、(0.62±0.30)mg/L,奶茶含氟量分别为(0.97±0.33)、(1.83±0.66)mg/L,成人尿含氟量分别为(1.29±0.55)、(1.47±0.62)mg/L,经奶茶摄氟量分别为(3.45±2.05)、(3.71±2.07) mg/d.罕达罕、哈达英格嘎查预防试验后砖茶、奶茶、成人尿含氟量和经奶茶摄氟量均明显低于预防试验前(t值分别为14.30、12.97,6.46、3.95,6.69、5.72,6.27、3.57,P均＜0.01),罕达罕嘎查经奶茶摄氟量在《人群总摄氟量卫生标准》(WS/T87-1996)允许限量内(＜ 3.5 mg/d).结论 饮低氟青砖茶可以预防饮茶型氟中毒,尤以含氟量为(204.5±10.2)mg/kg的低氟青砖茶预防效果更为可靠.
目的 觀察不同含氟量低氟青磚茶預防飲茶型氟中毒效果.方法 選擇內矇古剋什剋騰旂飲茶型氟中毒病區達來諾日鎮罕達罕、哈達英格嘎查作為預防試驗點,分彆投放含氟量為(204.5±10.2)、(308.2±15.4)mg/kg的低氟青磚茶12箇月.觀察指標包括預防試驗點病情[採用Dean法檢測20 ～ 70歲成人氟斑牙,臨床及Ⅹ線法檢測氟骨癥,併根據《地方性氟骨癥診斷標準》(WS 192-2008)進行診斷]和預防試驗前後磚茶、飲水、奶茶、成人尿含氟量(採用氟離子選擇電極法),併計算經奶茶的攝氟量.結果 預防試驗點罕達罕嘎查成人氟斑牙檢齣率為68.89％(62/90),臨床氟骨癥檢齣率為55.32％(52/94),Ⅹ線氟骨癥檢齣率為65.17％(58/89);哈達英格嘎查成人氟斑牙檢齣率為54.84％(51/93),臨床氟骨癥檢齣率為65.69％(67/102),Ⅹ線氟骨癥檢齣率為61.36％(54/88).罕達罕、哈達英格嘎查預防試驗前磚茶含氟量分彆為(831.4±138.9)、(864.3±134.6)mg/kg,飲水含氟量分彆為(0.27±0.05)、(0.54±0.24)mg/L,奶茶含氟量分彆為(2.16±1.12)、(2.82±1.38)mg/L,成人尿含氟量分彆為(2.78±1.57)、(2.96±1.80)mg/L,經奶茶攝氟量分彆為(8.12±5.84)、(6.42±5.04)mg/d;而預防試驗後磚茶含氟量分彆為(204.5±10.2)、(308.2±15.4)mg/kg,飲水含氟量分彆為(0.34±0.11)、(0.62±0.30)mg/L,奶茶含氟量分彆為(0.97±0.33)、(1.83±0.66)mg/L,成人尿含氟量分彆為(1.29±0.55)、(1.47±0.62)mg/L,經奶茶攝氟量分彆為(3.45±2.05)、(3.71±2.07) mg/d.罕達罕、哈達英格嘎查預防試驗後磚茶、奶茶、成人尿含氟量和經奶茶攝氟量均明顯低于預防試驗前(t值分彆為14.30、12.97,6.46、3.95,6.69、5.72,6.27、3.57,P均＜0.01),罕達罕嘎查經奶茶攝氟量在《人群總攝氟量衛生標準》(WS/T87-1996)允許限量內(＜ 3.5 mg/d).結論 飲低氟青磚茶可以預防飲茶型氟中毒,尤以含氟量為(204.5±10.2)mg/kg的低氟青磚茶預防效果更為可靠.
목적 관찰불동함불량저불청전다예방음다형불중독효과.방법 선택내몽고극십극등기음다형불중독병구체래낙일진한체한、합체영격알사작위예방시험점,분별투방함불량위(204.5±10.2)、(308.2±15.4)mg/kg적저불청전다12개월.관찰지표포괄예방시험점병정[채용Dean법검측20 ～ 70세성인불반아,림상급Ⅹ선법검측불골증,병근거《지방성불골증진단표준》(WS 192-2008)진행진단]화예방시험전후전다、음수、내다、성인뇨함불량(채용불리자선택전겁법),병계산경내다적섭불량.결과 예방시험점한체한알사성인불반아검출솔위68.89％(62/90),림상불골증검출솔위55.32％(52/94),Ⅹ선불골증검출솔위65.17％(58/89);합체영격알사성인불반아검출솔위54.84％(51/93),림상불골증검출솔위65.69％(67/102),Ⅹ선불골증검출솔위61.36％(54/88).한체한、합체영격알사예방시험전전다함불량분별위(831.4±138.9)、(864.3±134.6)mg/kg,음수함불량분별위(0.27±0.05)、(0.54±0.24)mg/L,내다함불량분별위(2.16±1.12)、(2.82±1.38)mg/L,성인뇨함불량분별위(2.78±1.57)、(2.96±1.80)mg/L,경내다섭불량분별위(8.12±5.84)、(6.42±5.04)mg/d;이예방시험후전다함불량분별위(204.5±10.2)、(308.2±15.4)mg/kg,음수함불량분별위(0.34±0.11)、(0.62±0.30)mg/L,내다함불량분별위(0.97±0.33)、(1.83±0.66)mg/L,성인뇨함불량분별위(1.29±0.55)、(1.47±0.62)mg/L,경내다섭불량분별위(3.45±2.05)、(3.71±2.07) mg/d.한체한、합체영격알사예방시험후전다、내다、성인뇨함불량화경내다섭불량균명현저우예방시험전(t치분별위14.30、12.97,6.46、3.95,6.69、5.72,6.27、3.57,P균＜0.01),한체한알사경내다섭불량재《인군총섭불량위생표준》(WS/T87-1996)윤허한량내(＜ 3.5 mg/d).결론 음저불청전다가이예방음다형불중독,우이함불량위(204.5±10.2)mg/kg적저불청전다예방효과경위가고.
Objective To investigate the effect of drinking brick tea with low-fluoride level on prevention of tea type fluorosis.Methods Handahangacha,Hadayinggegacha,Dalainuoyi town,in Keshiketengqi Inner Mongolia endemic fluorosis area were selected as test points,and brick tea with fluoride [(204.5 ± 10.2),(308.2 ±15.4)mg/kg] was given for 12 months.Dental fluorosis,clinical skeletal fluorosis,and X-ray diagnosis of skeletalfluorosis [according to “Endemic Skeletal Fluorosis Diagnostic Criteria” (WS 192-2008)] of adults 20 to 70 years of age were examined and level of fluoride before and after the prevention trial,in brick tea,drinking water,milk tea and urine were tested (fluoride ion selective electrode method),and fluoride intake through tea was calculated.Results Detection rate of adult dental fluorosis in Handahangacha was 68.89％ (62/90),clinical detection of skeletal fluorosis was 55.32％ (52/94),and X-ray detection of skeletal fluorosis was 65.17％ (58/89); adult dental fluorosis detection rate in Hadayinggegacha was 54.84％(51/93),clinical detection of skeletal fluorosis was 65.69％(67/102),and X-ray detection rate of skeletal fluorosis was 61.36％ (54/88).Brick tea fluoride was (831.4 ±138.9),(864.3 ± 134.6)mg/kg before the prevention trial in Handahangacha and Hadayinggegacha,respectively,drinking water fluoride content was (0.27 ± 0.05),(0.54 ± 0.24)mg/L,fluoride content of milk tea was (216 ± 1.12),(2.82 ± 1.38)mg/L,adult urine fluoride content was (2.78 ± 1.57),(2.96 ± 1.80)mg/L,and fluoride intake through milk tea was (8.12 ± 5.84),(6.42 ± 5.04)mg/d,respectively; after the prevention trial the fluoride content of brick tea was (204.5 ± 10.2),(308.2 ± 15.4)mg/kg,fluoride content of drinking water (0.34 ± 0.11),(0.62 ± 0.30)mg/L,fluoride content of milk tea(0.97 ± 0.33),(1.83 ± 0.66)mg/L,fluoride content in urine(1.29 ± 0.55),( 1.47 ±0.62)mg/L,fluoride intake through milk tea (3.45 ± 2.05),(3.71 ± 2.07)mg/d,respectively; in Handahan and Hadayinggegacha after the prevention trial the fluoride in brick tea,milk tea,urine fluoride,and fluoride intake through milk tea was significantly lower than that before the trial (t =14.30,12.97 ;6.46,3.95;6.69,5.72;6.27,3.57,all P ＜ 0.01 ).Fluoride intake in Handahangacha through milk tea was within the state heath standard limits( ＜ 3.5mg/d).Conclusion Drinking low-fluoride brick tea can prevent drinking brick tea type fluorosis,the preventive effect is especially more reliable with low fluoride brick tea (204.5 ± 10.2)mg/kg.
