国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2012年
2期
97-100
,共4页
陈雪%袁强%成岚%傅雪梅%李幼平%王乃红%王莉%周昌华
陳雪%袁彊%成嵐%傅雪梅%李幼平%王迺紅%王莉%週昌華
진설%원강%성람%부설매%리유평%왕내홍%왕리%주창화
白细胞滤过%血小板输注%发热性非溶血性输血反应%随机对照试验%Meta-分析
白細胞濾過%血小闆輸註%髮熱性非溶血性輸血反應%隨機對照試驗%Meta-分析
백세포려과%혈소판수주%발열성비용혈성수혈반응%수궤대조시험%Meta-분석
leukocyte-filtered%platelet transfusion%FNHTR%randomized controlled trial%Meta-analysis
目的 系统评价患者输注白细胞滤过的血小板(PLT)与普通PLT预防发热性非溶血性输血反应( FN HTR)的效果.方法 计算机检索PubMed,Embase,Cochrane图书馆和中国生物医学文献数据库,检索年限从建库至2010年12月.纳入白细胞滤过PLT与普通PLT比较预防FNHTR的随机对照试验.采用RevMan5.0软件进行Meta分析.结果 共纳入12篇文献.Meta分析结果显示:输注白细胞滤过的PLT发生FNHTR的风险仅为普通PLT的56％[RR=0.56,95％CI(0.39,0.82),P=0.003].PLT 保存前和保存后滤过白细胞对于FNHTR发生率的影响比较,差异无统计学意义[RR=0.41,95％ CI(0.15,1.14),P=0.09].结论 与输注普通PLT相比,输注白细胞过滤的PLT可降低FNHTR的发生率,但白细胞滤过时机对FNHTR的发生率无显著影响.
目的 繫統評價患者輸註白細胞濾過的血小闆(PLT)與普通PLT預防髮熱性非溶血性輸血反應( FN HTR)的效果.方法 計算機檢索PubMed,Embase,Cochrane圖書館和中國生物醫學文獻數據庫,檢索年限從建庫至2010年12月.納入白細胞濾過PLT與普通PLT比較預防FNHTR的隨機對照試驗.採用RevMan5.0軟件進行Meta分析.結果 共納入12篇文獻.Meta分析結果顯示:輸註白細胞濾過的PLT髮生FNHTR的風險僅為普通PLT的56％[RR=0.56,95％CI(0.39,0.82),P=0.003].PLT 保存前和保存後濾過白細胞對于FNHTR髮生率的影響比較,差異無統計學意義[RR=0.41,95％ CI(0.15,1.14),P=0.09].結論 與輸註普通PLT相比,輸註白細胞過濾的PLT可降低FNHTR的髮生率,但白細胞濾過時機對FNHTR的髮生率無顯著影響.
목적 계통평개환자수주백세포려과적혈소판(PLT)여보통PLT예방발열성비용혈성수혈반응( FN HTR)적효과.방법 계산궤검색PubMed,Embase,Cochrane도서관화중국생물의학문헌수거고,검색년한종건고지2010년12월.납입백세포려과PLT여보통PLT비교예방FNHTR적수궤대조시험.채용RevMan5.0연건진행Meta분석.결과 공납입12편문헌.Meta분석결과현시:수주백세포려과적PLT발생FNHTR적풍험부위보통PLT적56％[RR=0.56,95％CI(0.39,0.82),P=0.003].PLT 보존전화보존후려과백세포대우FNHTR발생솔적영향비교,차이무통계학의의[RR=0.41,95％ CI(0.15,1.14),P=0.09].결론 여수주보통PLT상비,수주백세포과려적PLT가강저FNHTR적발생솔,단백세포려과시궤대FNHTR적발생솔무현저영향.
Objective To systematically assess the effect of leukocyte-filtered platelet(PLT) and PLT concentrates transfusion on preventing febrile non-haemolytic transfusion reaction (FNHTR). Methods Such databases as PubMed, EMBASE, the Cochrane Library and CBM were searched from their establishment to December 2010.Randomized controlled trials were included. The Meta-analysis was conducted by Cochrane Collaboration's RevMan 5.0 software. Results 12 studies were selected to further Meta-analyses. The data showed that leukocyte-filtered PLT transfusion significantly decreased FNHTR [RR=0.56, 95％CI (0.39, 0.82), P＜0.0001] compared to PLT concentrates. Pre-storage leukocyte-filtered PLT transfusion had no significant difference of FNHTR compared to post-storage leukocyte-filtered PLT transfusion [RR=-0.41, 95％CI (0.15, 1.14), P=0.09]. Conclusions Leukocyte-filtered PLT transfusion could prevent FNHTR more effectively than PLT concentrates independent on filtering time.
