中华医学遗传学杂志
中華醫學遺傳學雜誌
중화의학유전학잡지
CHINESE JOURNAL OF MEDICAL GENETICS
2009年
2期
161-164
,共4页
2型糖尿病%肥胖%高血压%遗传率%遗传相关
2型糖尿病%肥胖%高血壓%遺傳率%遺傳相關
2형당뇨병%비반%고혈압%유전솔%유전상관
type 2 diabetes mellitus%obesity%hypertension%heritability%genetic correlation
目的 研究空腹血糖的遗传率及其与肥胖相关人体测量学指标和血压的遗传相关.方法 分析由1383个个体组成的218个2型糖尿病家系,采用单变量方差分解分析估计空腹血糖,人体测量学指标和血压的狭义遗传率(h2),双变量数量性状遗传分析估计空腹血糖和人体测量学指标及血压间的遗传及环境相关.结果 空腹血糖,血压和除腰臀比之外的人体测量学指标都受显著的遗传决定作用,h<'2>的范围为0.28～0.43.空腹血糖与肥胖相关人体测量学指标等数量性状之间的遗传或环境相关分析未发现显著结果.结论 本研究结果表明2型糖尿病,高血压和肥胖为一定的遗传因素所控制,而空腹血糖与肥胖相关人体测量学指标及血压间无显著的遗传或环境相关.
目的 研究空腹血糖的遺傳率及其與肥胖相關人體測量學指標和血壓的遺傳相關.方法 分析由1383箇箇體組成的218箇2型糖尿病傢繫,採用單變量方差分解分析估計空腹血糖,人體測量學指標和血壓的狹義遺傳率(h2),雙變量數量性狀遺傳分析估計空腹血糖和人體測量學指標及血壓間的遺傳及環境相關.結果 空腹血糖,血壓和除腰臀比之外的人體測量學指標都受顯著的遺傳決定作用,h<'2>的範圍為0.28～0.43.空腹血糖與肥胖相關人體測量學指標等數量性狀之間的遺傳或環境相關分析未髮現顯著結果.結論 本研究結果錶明2型糖尿病,高血壓和肥胖為一定的遺傳因素所控製,而空腹血糖與肥胖相關人體測量學指標及血壓間無顯著的遺傳或環境相關.
목적 연구공복혈당적유전솔급기여비반상관인체측량학지표화혈압적유전상관.방법 분석유1383개개체조성적218개2형당뇨병가계,채용단변량방차분해분석고계공복혈당,인체측량학지표화혈압적협의유전솔(h2),쌍변량수량성상유전분석고계공복혈당화인체측량학지표급혈압간적유전급배경상관.결과 공복혈당,혈압화제요둔비지외적인체측량학지표도수현저적유전결정작용,h<'2>적범위위0.28～0.43.공복혈당여비반상관인체측량학지표등수량성상지간적유전혹배경상관분석미발현현저결과.결론 본연구결과표명2형당뇨병,고혈압화비반위일정적유전인소소공제,이공복혈당여비반상관인체측량학지표급혈압간무현저적유전혹배경상관.
Objective To study the genetic determination of fast plasma glucose (FPG) and correlation with its potential correlated traits, anthropometric measures and blood pressure. Methods Two hundred and eighteen Type 2 diabetes mellitus(T2DM) pedigrees composed of 1383 Chinese Han individuals residing in the East and South-East China were analyzed. Univariate variance decomposition analyses were used to estimate the narrow-sense heritability (h2) of FPG, anthropometric indices and blood pressure, and bivariate quantitative genetic analyses were used to estimate the genetic and environmental correlations between FPG and anthropometric measures or blood pressure. Results We found that FPG, blood pressure and all anthropometric indices except for waist to hip ratio were under significant genetic determination, and the h2 was from 0.28 to 0.43. We did not find significant genetic and environmental correlation between FPG and anthropometric indices and blood pressure. Conclusion The present study demonstrated that T2DM, obesity and hypertension were controlled by some genetic factors, and FPG shares little common genetic and environmental factors with obesity-related anthropometric indices and blood pressure in our Chinese sample population.
