CAJ | 학술논문

目的探讨胸腺肽α_1对老年慢性阻塞性肺疾病(COPD)患者急性加重的预防作用及其机制.方法将120例老年COPD急性加重期治疗稳定后的患者随机分成治疗组和对照组,每组各60例.对照组单纯给予临床观察,治疗组给予胸腺肽α_1 1.6 mg皮下注射,每周2次,共2个月.观察1年,每2周随访一次,并于治疗前、治疗后2个月及1年时检查患者血清CD3、CD4、CD8和IgA、IgG、IgM水平及肺功能.结果在治疗后1年内,治疗组患者再次发生急性加重的间隔时间为(110±48)d,比对照组的(92±47)d明显延长(P＜0.05);发生急性加重的次数为(2.4±1.1)次,比对照组的(3.1±0.9)次明显减少(P＜0.05);发作时间为(26±13)d,比对照组的(34±11)d明显减少(P＜0.05);治疗组患者经治疗后,CD4及CIM/CD8比值明显升高(P＜0.05).结论胸腺肽α_1通过增强患者细胞免疫功能,可有效地预防COPD的急性加重.
목적 탐토흉선태α_1대노년만성조새성폐질병(COPD)환자급성가중적예방작용급기궤제.방법 장120례노년COPD급성가중기치료은정후적환자수궤분성치료조화대조조,매조각60례.대조조단순급여림상관찰,치료조급여흉선태α_1 1.6 mg피하주사,매주2차,공2개월.관찰1년,매2주수방일차,병우치료전、치료후2개월급1년시검사환자혈청CD3、CD4、CD8화IgA、IgG、IgM수평급폐공능.결과 재치료후1년내,치료조환자재차발생급성가중적간격시간위(110±48)d,비대조조적(92±47)d명현연장(P＜0.05);발생급성가중적차수위(2.4±1.1)차,비대조조적(3.1±0.9)차명현감소(P＜0.05);발작시간위(26±13)d,비대조조적(34±11)d명현감소(P＜0.05);치료조환자경치료후,CD4급CIM/CD8비치명현승고(P＜0.05).결론 흉선태α_1통과증강환자세포면역공능,가유효지예방COPD적급성가중.
Objective To investigate the prophylactic effect of thymosin α_1 on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)in elderly patients.Methods One hundred and twenty COPD patients were randomized into two groups(n=60 for each).Patients in the treatment group received thymosin α_1 1.6 mg subcutaneously,2/week for 8 weeks;while patients in control group received normal saline instead.Serum CD3,CD4,CD8,IrA,IgG and IgM levers were measured,and the pulmonary function were examined before and 2.12 months after treatment.Results In treatment group the recurrence interval of AECOPD Was extended:the attack frequency and persistence time of AECOPD were significantly lower in cutuparison with those of the control group(P＜0.05).CD4 and CD4/CD8 levels were significanfly increased(P＜0.05)after treatment of thymosincd.Conclusion Thymosin α_1 Can protect acute exacerbation of chronic obstructive pulmonary disease in elderly patients.