CAJ | 학술논문

目的分析1999至2008年新疆维吾尔自治区人民医院高血压专科住院患者病因构成及演变趋势.方法采用回顾性研究方法 ,分析10年间7809例高血压专科住院患者的病因构成及在各年度分布情况,并对变化趋势进行分析.结果 (1)7809例高血压专科住院患者中原发性高血压5867例,占75.1%,继发性高血压1942例,占24.9%.(2)2008年和1999年继发性高血压所占的比例分别为39.3%(665/1692)、9.5%(32/338).10年间继发性高血压所占的比例逐年升高(χ2=387.621,P＜0.001＝.病因构成中,睡眠呼吸暂停综合征(OSAS)2008年占20.3%(343/1692),1999年占0.6%(2/338)(χ2=304.025,P＜0.001＝;原发性醛固酮增多症(PA)2008年占5.3%(89/1692),1999年占2.9%(10/338)(χ2=42.845,P＜0.001＝;其他病因所占比例变化较小.(3)2004至2008年PA合并OSAS比例逐年升高(χ2=26.376,P＜0.001＝,PA中OSAS占23.9%(65/272),OSAS中PA占6.7%(65/963).结论 1999至2008年高血压住院患者中,继发性高血压所占的比例逐年升高.在继发性高血压中,OSAS、PA所占的比例最高,同时应注意OSAS与PA两种继发性因素可能并存.
목적 분석1999지2008년신강유오이자치구인민의원고혈압전과주원환자병인구성급연변추세.방법 채용회고성연구방법 ,분석10년간7809례고혈압전과주원환자적병인구성급재각년도분포정황,병대변화추세진행분석.결과 (1)7809례고혈압전과주원환자중원발성고혈압5867례,점75.1%,계발성고혈압1942례,점24.9%.(2)2008년화1999년계발성고혈압소점적비례분별위39.3%(665/1692)、9.5%(32/338).10년간계발성고혈압소점적비례축년승고(χ2=387.621,P＜0.001＝.병인구성중,수면호흡잠정종합정(OSAS)2008년점20.3%(343/1692),1999년점0.6%(2/338)(χ2=304.025,P＜0.001＝;원발성철고동증다증(PA)2008년점5.3%(89/1692),1999년점2.9%(10/338)(χ2=42.845,P＜0.001＝;기타병인소점비례변화교소.(3)2004지2008년PA합병OSAS비례축년승고(χ2=26.376,P＜0.001＝,PA중OSAS점23.9%(65/272),OSAS중PA점6.7%(65/963).결론 1999지2008년고혈압주원환자중,계발성고혈압소점적비례축년승고.재계발성고혈압중,OSAS、PA소점적비례최고,동시응주의OSAS여PA량충계발성인소가능병존.
Objective To analyze etiology of hospitalized hypertensive patients in the department of hypertension from 1999 to 2008. Methods This retrospective study was performed to analyze the etiology of hospitalized hypertensive patients in department of hypertension and to show the distribution change of hypertension from 1999 to 2008. Results ( 1 ) There were 5867 ( 75. 1% ) patients with essential hypertension and 1942 (24. 9% ) patients with secondary hypertension (SH). (2) The prevalence rate of SH increased significantly during the 10 years (χ2 = 387.621 ,P ＜ 0.001 ) and was higher in 2008 than in 1999 (39. 3% vs. 9. 5% , P ＜ 0. 05 ). The prevalence of obstructive sleep apnea syndrome (OSAS) and primary aldosteronism (PA) in 2008 increased 38.3 and 1.8 times respectively than in 1999 (χ2 =304. 025 ,P ＜0. 001; χ2 =42. 845 ,P ＜0. 001 ) and other SH remained unchanged. ( 3 ) The prevalence of PA complicated with OSAS increased significantly in recent five years ( χ2 = 26.376, P ＜0. 001 ). Incidence of OSAS was 23.9% in PA patients and incidence of PA was 6. 7% in OSAS patients. Conclusions With the insights gained on hypertension mechanism and the development of new diagnostic technology, percent of diagnosed SH increased remarkably in recent years in hospitalized hypertensive patients in our department of hypertension. OSAS and PA are the leading causes of SH.