7-(4-芳酰基硫脲)诺氟沙星衍生物的合成与结构表征
7-(4-방선기류뇨)낙불사성연생물적합성여결구표정
Synthesis and structural characterization of 7-(4-aryl acyl thiourea) norflorxacin derivatives
  • 万方数据
    化学试剂 화학시제
    CHEMICAL REAGENTS
    2010年 2期 183-185 ,共3页

    史大斌%汪彦屿%刘静姿%胡成兵

    사대빈%왕언서%류정자%호성병

    芳酰基硫脲%诺氟沙星%硫代异氰酸酯%抗菌药%合成 芳酰基硫脲%諾氟沙星%硫代異氰痠酯%抗菌藥%閤成
    방선기류뇨%낙불사성%류대이청산지%항균약%합성
    aryl acyl thiourea%norflorxacin%isosulfocyanic ester%antibacterial compounds%synthesis
    为了寻找高效新型含氟喹诺酮类抗菌药,将芳基酰氯与硫氰酸钠反应并经分子内重排生成的芳酰基硫代异氰酸酯,通过对诺氟沙星7-位哌嗪基进行修饰,合成了5个未见文献报道的7-(4-芳酰基硫脲)诺氟沙星的衍生物,其结构经IR、1HNMR、MS、元素分析确证.
    위료심조고효신형함불규낙동류항균약,장방기선록여류청산납반응병경분자내중배생성적방선기류대이청산지,통과대낙불사성7-위고진기진행수식,합성료5개미견문헌보도적7-(4-방선기류뇨)낙불사성적연생물,기결구경IR、1HNMR、MS、원소분석학증.
    In order to search for novel fluoroquinolone analogues with high biological activities as antibacterial compounds,aryl acyl isosulfocyanic ester was prepared by reaction of aryl acyl chloride with sodium sulfocyanate.Five novel 7-(4-aryl acyl thiourea) norflorxacin derivatives were synthesized through modifying the 7-piperazine of norflorxacin with isosulfocyanic ester.Their structures were characterized by means of FT-IR,1HNMR and elemental analysis.
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