国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
3期
145-150
,共6页
杨帆%叶仁青%陈容平%杨力%孙嘉%蔡德鸿
楊帆%葉仁青%陳容平%楊力%孫嘉%蔡德鴻
양범%협인청%진용평%양력%손가%채덕홍
肥胖指标%2型糖尿病%高血压%血脂异常
肥胖指標%2型糖尿病%高血壓%血脂異常
비반지표%2형당뇨병%고혈압%혈지이상
Adiposity indicators%Type 2 diabetes mellitus%Hypertension%Dyslipidemia
目的 比较体重指数(BMI)、腰围(WC)、腰臀比( WHR)、腰围身高比(WHtR)对预测2型糖尿病(T2DM)、高血压及血脂异常风险的效果,筛选最佳肥胖评定指标,寻求早期临床干预的切点.方法 对广州市海珠区650名45岁以上未诊断过T2DM的常住居民进行调查,应用受试者工作特征曲线(ROC)比较4种肥胖指标对疾病的预测效果.结果 4种肥胖指标预测T2DM、高血压和血脂异常的最佳切点分别为,男性BMI 23.63、23.63和23.32 kg/m2,WC 84.50、84.50和78.50 cm,WHR 0.888 3、0.8405和0.873 1,WHtR 0.498 5、0.494 0和0.461 3,女性BMI 23.47、25.00和24.12 kg/m2,WC 76.75、81.50和77.50 cm,WHR0.822 9、0.834 1和0.804 2,WHtR 0.496 9、0.527 8和0.456 0.女性人群中4种指标预测T2DM的曲线下面积(AUC)无显著差异.BMI在预测男性T2DM、高血压、血脂异常及女性高血压时的AUC明显小于其他肥胖指标(P＜0.05).结论 广州社区中老年人群中中心性肥胖指标较全身性肥胖指标与代谢综合征亚组的关系更加密切,针对不同性别、年龄和生理状态的人群采用适合的诊断切点或将肥胖指标整合利用,能够有效提高其对疾病的预测价值.
目的 比較體重指數(BMI)、腰圍(WC)、腰臀比( WHR)、腰圍身高比(WHtR)對預測2型糖尿病(T2DM)、高血壓及血脂異常風險的效果,篩選最佳肥胖評定指標,尋求早期臨床榦預的切點.方法 對廣州市海珠區650名45歲以上未診斷過T2DM的常住居民進行調查,應用受試者工作特徵麯線(ROC)比較4種肥胖指標對疾病的預測效果.結果 4種肥胖指標預測T2DM、高血壓和血脂異常的最佳切點分彆為,男性BMI 23.63、23.63和23.32 kg/m2,WC 84.50、84.50和78.50 cm,WHR 0.888 3、0.8405和0.873 1,WHtR 0.498 5、0.494 0和0.461 3,女性BMI 23.47、25.00和24.12 kg/m2,WC 76.75、81.50和77.50 cm,WHR0.822 9、0.834 1和0.804 2,WHtR 0.496 9、0.527 8和0.456 0.女性人群中4種指標預測T2DM的麯線下麵積(AUC)無顯著差異.BMI在預測男性T2DM、高血壓、血脂異常及女性高血壓時的AUC明顯小于其他肥胖指標(P＜0.05).結論 廣州社區中老年人群中中心性肥胖指標較全身性肥胖指標與代謝綜閤徵亞組的關繫更加密切,針對不同性彆、年齡和生理狀態的人群採用適閤的診斷切點或將肥胖指標整閤利用,能夠有效提高其對疾病的預測價值.
목적 비교체중지수(BMI)、요위(WC)、요둔비( WHR)、요위신고비(WHtR)대예측2형당뇨병(T2DM)、고혈압급혈지이상풍험적효과,사선최가비반평정지표,심구조기림상간예적절점.방법 대엄주시해주구650명45세이상미진단과T2DM적상주거민진행조사,응용수시자공작특정곡선(ROC)비교4충비반지표대질병적예측효과.결과 4충비반지표예측T2DM、고혈압화혈지이상적최가절점분별위,남성BMI 23.63、23.63화23.32 kg/m2,WC 84.50、84.50화78.50 cm,WHR 0.888 3、0.8405화0.873 1,WHtR 0.498 5、0.494 0화0.461 3,녀성BMI 23.47、25.00화24.12 kg/m2,WC 76.75、81.50화77.50 cm,WHR0.822 9、0.834 1화0.804 2,WHtR 0.496 9、0.527 8화0.456 0.녀성인군중4충지표예측T2DM적곡선하면적(AUC)무현저차이.BMI재예측남성T2DM、고혈압、혈지이상급녀성고혈압시적AUC명현소우기타비반지표(P＜0.05).결론 엄주사구중노년인군중중심성비반지표교전신성비반지표여대사종합정아조적관계경가밀절,침대불동성별、년령화생리상태적인군채용괄합적진단절점혹장비반지표정합이용,능구유효제고기대질병적예측개치.
Objective To evaluate the values of body mass index (BMI),waist circumference (WC),waist-to-hip ratio (WHR) and waist-to-height ratio(WHtR) in predicting the risk of type 2 diabetes mellitus(T2DM),hypertension and dyslipidemia,to screen for the best adiposity indicator and determine the optimal cutoff points for early clinical intervention.Methods A total of 650 permanent residents aged more than 45 years in Haizhu District in Guangzhou and not dignosed of T2DM were selected.The receiver operating characteristic(ROC) curves were used to determine the best and reference cutoff value of the four indicators.Results The optimal cutoff points of 4 adiposity indicators in predicting the risk of T2DM,hypertension and dyslipidemia for men,respectively,were 23.63,23.63 and 23.32 kg/m2 for BMI ; 84.50,84.50and 78.50 cm for WC ; 0.888 3,0.840 5 and 0.873 1 for WHR; 0.498 5,0.494 0 and 0.461 3 forWHtR.And the optimal cutoff points for women,respectively,were 23.47,25.00 and 24.12 kg/m2 for BMI; 76.75,81.50 and 77.50 cm for WC; 0.822 9,0.834 1 and 0.804 2 for WHR; 0.496 9,0.527 8and 0.456 0 for WHtR.Area under the curve(AUCs) were not significantly different among the indicators for T2DM in women.AUCs of BMI in predicting T2DM,hypertension and dyslipidemia in men and hypertension in women were generally small compared with other adiposity indicators( P ＜ 0.05 ).Conclusions Central adiposity indicators are strongly associated with metabolic syndrome subgroups rather than general adiposity indicators in the elderly population in Guangzhou communities.Appropriate diagnostic cutoff points for different gender,age and physiological state of the population,or integrate the use of adiposity indicators can improve their predictive values of diseases effectively.
