国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2011年
5期
497-500
,共4页
γ-谷氨酰水解酶%基因多态性%甲氨蝶呤%药物敏感性
γ-穀氨酰水解酶%基因多態性%甲氨蝶呤%藥物敏感性
γ-곡안선수해매%기인다태성%갑안접령%약물민감성
Gamma-Glutamyl hydrolase%Genetic polymorphisms%Methotrexate%Drug sensitivity
γ-谷氨酰水解酶(GGH)是甲氨蝶呤(MTX)聚谷氨酸化的一种关键酶，高水平的GGH与MTX的耐药有关。近来研究发现GGH基因单核苷酸多态性可使该基因表达和催化活性发生改变，导致MTX的细胞毒作用产生个体差异。该文就GGH的结构功能特点及其基因多态性与MTX药物敏感性关系的研究进展进行综述。
γ-穀氨酰水解酶(GGH)是甲氨蝶呤(MTX)聚穀氨痠化的一種關鍵酶，高水平的GGH與MTX的耐藥有關。近來研究髮現GGH基因單覈苷痠多態性可使該基因錶達和催化活性髮生改變，導緻MTX的細胞毒作用產生箇體差異。該文就GGH的結構功能特點及其基因多態性與MTX藥物敏感性關繫的研究進展進行綜述。
γ-곡안선수해매(GGH)시갑안접령(MTX)취곡안산화적일충관건매，고수평적GGH여MTX적내약유관。근래연구발현GGH기인단핵감산다태성가사해기인표체화최화활성발생개변，도치MTX적세포독작용산생개체차이。해문취GGH적결구공능특점급기기인다태성여MTX약물민감성관계적연구진전진행종술。
Gamma-glutamyl hydrolase (GGH) plays an important role in methotrexate (MTX)polyglutarmation. High level of GGH has been associated with cellular resistance to MTX. Recent studies have demonstrate that some polymorphisms of GGH could change the expression and catalytic activity of the enzyme,causing interindividual difference in MTX cytotoxicity. No study about GGH was reported in Chinese population. This paper reviewed the advances about the structure and function of GGH and its gene, and the advances in associations between polymorphisms of GGH and MTX sensitivity.
