中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
3期
295-296
,共2页
袁耿彪%匡安仁%范群%郭兴%王全林%管昌田%于南
袁耿彪%劻安仁%範群%郭興%王全林%管昌田%于南
원경표%광안인%범군%곽흥%왕전림%관창전%우남
全反式维甲酸%失分化型甲状腺癌%诱导%不良反应
全反式維甲痠%失分化型甲狀腺癌%誘導%不良反應
전반식유갑산%실분화형갑상선암%유도%불량반응
All trans retinoic acid%Dedifferentiated thyroid carcinoma%Induction%Toxicity
应用全反式维甲酸(ATRA)诱导失分化型甲状腺癌(dDTC)患者,5例患者(5/9,55.6%)ATRA诱导有效;5例患者(5/8,62.5%)131I治疗获益.3例患者(3/12,25.O%)因神经系统的不良反应,不能耐受而放弃ATRA诱导.ATRA是诱导dDTC分化的有效方法,可以提高dDTC病灶的摄碘能力,但使用中应关注ATRA的不良反应.
應用全反式維甲痠(ATRA)誘導失分化型甲狀腺癌(dDTC)患者,5例患者(5/9,55.6%)ATRA誘導有效;5例患者(5/8,62.5%)131I治療穫益.3例患者(3/12,25.O%)因神經繫統的不良反應,不能耐受而放棄ATRA誘導.ATRA是誘導dDTC分化的有效方法,可以提高dDTC病竈的攝碘能力,但使用中應關註ATRA的不良反應.
응용전반식유갑산(ATRA)유도실분화형갑상선암(dDTC)환자,5례환자(5/9,55.6%)ATRA유도유효;5례환자(5/8,62.5%)131I치료획익.3례환자(3/12,25.O%)인신경계통적불량반응,불능내수이방기ATRA유도.ATRA시유도dDTC분화적유효방법,가이제고dDTC병조적섭전능력,단사용중응관주ATRA적불량반응.
The patients with dedifferentiated thyroid carcinoma were induced by all-trans retinoic acid (ATRA). The treatment was effective in 5 patients (5/9,55.6%), and 5 patients were benefited from following 131 I treatment(5/8, 62.5% ). Three patients(3/12,25.0% ) quitted because of neurological side-effects. It is efficacious to apply ATRA to induce dedifferentiated thyroid carcinoma and improve radio-iodine uptake and acquire benefit for patients, but clinic application of ATRA must be cautious.
