几种治疗绝经后妇女骨量减少干预方案疗效及安全性的比较
궤충치료절경후부녀골량감소간예방안료효급안전성적비교
Comparison of several early drug interventions in postmenopausal women with osteopenia
  • 万方数据
    中华内分泌代谢杂志 중화내분비대사잡지
    CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
    2011年 6期 502-504 ,共3页

    游利%盛正妍%戴俊明%陈瑾瑜%潘凌%陈琳%王士中%吴恒%季晨%周建%彭永德

    유리%성정연%대준명%진근유%반릉%진림%왕사중%오항%계신%주건%팽영덕

    骨量减少%骨密度%骨质疏松,绝经后 骨量減少%骨密度%骨質疏鬆,絕經後
    골량감소%골밀도%골질소송,절경후
    Osteopenia%Bone mineral density%Osteoporosis,postmenopausal
    200例骨量减少、年龄在45～80岁的绝经后妇女随机分为4组,进行不同干预方案治疗,治疗12个月后,双膦酸盐(固邦)组骨密度提高最明显(腰椎为3.5%,全髋为2.6%,均P＜0.05),选择性雌激素受体调节剂(贝邦)组(腰椎为2.0%,P＜0.05),骨转换指标均改善(均P＜0.05),活性维生素D(萌格旺)和钙剂(钙尔奇D)组骨密度和骨转换指标均无明显改变.
    200례골량감소、년령재45～80세적절경후부녀수궤분위4조,진행불동간예방안치료,치료12개월후,쌍련산염(고방)조골밀도제고최명현(요추위3.5%,전관위2.6%,균P＜0.05),선택성자격소수체조절제(패방)조(요추위2.0%,P＜0.05),골전환지표균개선(균P＜0.05),활성유생소D(맹격왕)화개제(개이기D)조골밀도화골전환지표균무명현개변.
    Two hundreds postmenopausal women with osteopenia, aged 45-80, were randomly divided into 4 groups, and received different drug interventions. After treatment for 12 months, the lumbar spine bone mineral density(BMD)and total hip BMD in alendronate group increased significantly(3.5% and 2.6%, both P＜0.05), the lumbar spine BMD raised 2.0% in selective estrogen receptor regulator group(P＜0.05). Bone turnover indices improved in both groups(all P＜0.05). No change in BMD or bone turnover indices was found in patients treated with active vitamin D3and calcium.
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