中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
12期
1139-1141
,共3页
脂肪肝%肝功能不全%代谢综合征
脂肪肝%肝功能不全%代謝綜閤徵
지방간%간공능불전%대사종합정
Fatty liver%Hepatic imsufficiency%Metabolic syndrome
目的 探讨非酒精性脂肪肝(NAFLD)患者不同肝损害程度与代谢综合征(MS)各组分之间的关系.方法 1151例NAFLD患者以及年龄、性别相匹配的4113例健康对照人群均来自我院体检中心.所有研究对象均进行身高、体重、血压、血脂、血糖、肝炎系列等指标的检测,空腹行腹部彩超检查.分析并比较检测的各项结果.结果 1151例超声诊断NAFLD患者中轻度767例,中度345例,重度39例,MS检出例数分别为218、144和20例,检出率分别为28.4%、41.7%和51.3%,显著高于健康对照组(7.8%),且随超声诊断脂肪肝的严重程度逐渐递增(P＜0.01);ALT正常者905例,升高者246例,其中血脂紊乱、超重或肥胖和MS的检出率分别为54.6%、66.6%、31.9%和71.5%、82.5%、37.8%,均显著高于健康对照组(24.3%、32.4%和7.7%),且随ALT升高而逐渐递增(P＜0.05).但NAFLD组高血压、高血糖检出率与健康对照组相比差异无统计学意义(P＞0.05).结论 NFALD患者肝损害程度与代谢综合征各组分关系密切,尤其与肥胖、血脂紊乱密切相关,因此,应重视NAFLD患者的调脂减肥治疗.
目的 探討非酒精性脂肪肝(NAFLD)患者不同肝損害程度與代謝綜閤徵(MS)各組分之間的關繫.方法 1151例NAFLD患者以及年齡、性彆相匹配的4113例健康對照人群均來自我院體檢中心.所有研究對象均進行身高、體重、血壓、血脂、血糖、肝炎繫列等指標的檢測,空腹行腹部綵超檢查.分析併比較檢測的各項結果.結果 1151例超聲診斷NAFLD患者中輕度767例,中度345例,重度39例,MS檢齣例數分彆為218、144和20例,檢齣率分彆為28.4%、41.7%和51.3%,顯著高于健康對照組(7.8%),且隨超聲診斷脂肪肝的嚴重程度逐漸遞增(P＜0.01);ALT正常者905例,升高者246例,其中血脂紊亂、超重或肥胖和MS的檢齣率分彆為54.6%、66.6%、31.9%和71.5%、82.5%、37.8%,均顯著高于健康對照組(24.3%、32.4%和7.7%),且隨ALT升高而逐漸遞增(P＜0.05).但NAFLD組高血壓、高血糖檢齣率與健康對照組相比差異無統計學意義(P＞0.05).結論 NFALD患者肝損害程度與代謝綜閤徵各組分關繫密切,尤其與肥胖、血脂紊亂密切相關,因此,應重視NAFLD患者的調脂減肥治療.
목적 탐토비주정성지방간(NAFLD)환자불동간손해정도여대사종합정(MS)각조분지간적관계.방법 1151례NAFLD환자이급년령、성별상필배적4113례건강대조인군균래자아원체검중심.소유연구대상균진행신고、체중、혈압、혈지、혈당、간염계렬등지표적검측,공복행복부채초검사.분석병비교검측적각항결과.결과 1151례초성진단NAFLD환자중경도767례,중도345례,중도39례,MS검출례수분별위218、144화20례,검출솔분별위28.4%、41.7%화51.3%,현저고우건강대조조(7.8%),차수초성진단지방간적엄중정도축점체증(P＜0.01);ALT정상자905례,승고자246례,기중혈지문란、초중혹비반화MS적검출솔분별위54.6%、66.6%、31.9%화71.5%、82.5%、37.8%,균현저고우건강대조조(24.3%、32.4%화7.7%),차수ALT승고이축점체증(P＜0.05).단NAFLD조고혈압、고혈당검출솔여건강대조조상비차이무통계학의의(P＞0.05).결론 NFALD환자간손해정도여대사종합정각조분관계밀절,우기여비반、혈지문란밀절상관,인차,응중시NAFLD환자적조지감비치료.
Objective To evaluate the relation between liver damage and metabolic syndrome(MS) in patients with nonalcoholil fatty liver disease (NAFLD). Indexes of height, weight, blood pressure, blood lipids, blood sugar, hepatitis series and abdominal color doppler ultrasound examination were conducted. Methods Total 1151patients with NAFLD and 4113 healthy people matched by age and sex were analyzed. Indexes of height,weight,blood pressure ,blood lipids,blood sugar, hepatitis series and abdominal color Doppler ultrasound examination were conducted. Results Total 767 patients had mild fatty liver, 345 patients had moderate fatty liver and 39 patients had severe fatty liver. The prevalence of MS was respectively 28.4% (218/767 ),41.7% (144/345 ) and 51.3 %(20/39), significantly higher than that in the control group (7.8%) ,and it gradually increased with the severity of sonographic fatty liver. 905 cases with normal ALT level and 246 cases with increased ALT level were detected in 1151 patients with sonographic fatty liver based on ALT test and rates dyslipidemia. The prevalence of overweight or obesity, dyslipidemia and MS was significantly higher in patients with nonalcoholic fatty liver disease than that in healthy controls, and it gradually increased with the increasing of ALT. But there was no significant difference in hypertension and hyperglycemia between nonalcoholic fatty liver disease and healthy control group. Conclusions The nonalcoholic sonographically fatty liver is strongly associated with the components of MS, especially with obesity and dyslipidemia. Measures must be taken to control body weight and to lower lipid in patient with nonalcoholic fatty liver disease.
