肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
1期
20-23
,共4页
尹宜发%徐弘%李思维%周海波%李欣%邹立勇
尹宜髮%徐弘%李思維%週海波%李訢%鄒立勇
윤의발%서홍%리사유%주해파%리흔%추립용
乳腺肿瘤%肿瘤抑制蛋白p53%环氧化酶2%预后
乳腺腫瘤%腫瘤抑製蛋白p53%環氧化酶2%預後
유선종류%종류억제단백p53%배양화매2%예후
Breast neoplasms%Tumor suppressor protein p53%Cyclooxygenase 2%Prognosis
目的 探讨环氧合酶2(COX-2)和p53蛋白在乳腺癌组织中的表达及其与乳腺癌预后的关系.方法 用免疫组化法检测152例乳腺癌组织和16例正常乳腺组织COX-2和p53蛋白表达情况通过生存分析研究它们与预后的关系.结果 COX-2与p53在正常乳腺组织均不表达.COX-2和p53蛋白在乳腺癌组织中的表达率分别为58.6％(89/152)、61.2％(93/152),二者呈显著相关性(r=0.426P＜ 0.01)；二者表达在Ⅰ、Ⅱ级乳腺癌组织中均显著相关(r值分别为0.414,0.381,均P＜0.01),在Ⅲ级乳腺癌组织中二者无相关性(P＞0.05).Ⅰ、Ⅱ、Ⅲ、Ⅳ期乳腺癌COX-2、p53表达均显著相关(r值分别为0.659,0.557,0.390,0.685,均P＜ 0.01).两者表达与淋巴结、远处转移均相关(均P＜0.05).COX-2高表达组的5年无进展生存( PFS)率显著低于低表达者,但p53高表达组与低表达组的5年PFS率差异无统计学意义.COX-2与p53均高表达者的5年PFS低于COX-2或p53单一高表达者,亦低于两者均双低f表达者.结论 COX-2和p53的表达与临床分期、淋巴结转移、远处转移、病理分级等临床预后不良因素有关.检测COX-2和p53对乳腺癌的预后有重要价值.
目的 探討環氧閤酶2(COX-2)和p53蛋白在乳腺癌組織中的錶達及其與乳腺癌預後的關繫.方法 用免疫組化法檢測152例乳腺癌組織和16例正常乳腺組織COX-2和p53蛋白錶達情況通過生存分析研究它們與預後的關繫.結果 COX-2與p53在正常乳腺組織均不錶達.COX-2和p53蛋白在乳腺癌組織中的錶達率分彆為58.6％(89/152)、61.2％(93/152),二者呈顯著相關性(r=0.426P＜ 0.01)；二者錶達在Ⅰ、Ⅱ級乳腺癌組織中均顯著相關(r值分彆為0.414,0.381,均P＜0.01),在Ⅲ級乳腺癌組織中二者無相關性(P＞0.05).Ⅰ、Ⅱ、Ⅲ、Ⅳ期乳腺癌COX-2、p53錶達均顯著相關(r值分彆為0.659,0.557,0.390,0.685,均P＜ 0.01).兩者錶達與淋巴結、遠處轉移均相關(均P＜0.05).COX-2高錶達組的5年無進展生存( PFS)率顯著低于低錶達者,但p53高錶達組與低錶達組的5年PFS率差異無統計學意義.COX-2與p53均高錶達者的5年PFS低于COX-2或p53單一高錶達者,亦低于兩者均雙低f錶達者.結論 COX-2和p53的錶達與臨床分期、淋巴結轉移、遠處轉移、病理分級等臨床預後不良因素有關.檢測COX-2和p53對乳腺癌的預後有重要價值.
목적 탐토배양합매2(COX-2)화p53단백재유선암조직중적표체급기여유선암예후적관계.방법 용면역조화법검측152례유선암조직화16례정상유선조직COX-2화p53단백표체정황통과생존분석연구타문여예후적관계.결과 COX-2여p53재정상유선조직균불표체.COX-2화p53단백재유선암조직중적표체솔분별위58.6％(89/152)、61.2％(93/152),이자정현저상관성(r=0.426P＜ 0.01)；이자표체재Ⅰ、Ⅱ급유선암조직중균현저상관(r치분별위0.414,0.381,균P＜0.01),재Ⅲ급유선암조직중이자무상관성(P＞0.05).Ⅰ、Ⅱ、Ⅲ、Ⅳ기유선암COX-2、p53표체균현저상관(r치분별위0.659,0.557,0.390,0.685,균P＜ 0.01).량자표체여림파결、원처전이균상관(균P＜0.05).COX-2고표체조적5년무진전생존( PFS)솔현저저우저표체자,단p53고표체조여저표체조적5년PFS솔차이무통계학의의.COX-2여p53균고표체자적5년PFS저우COX-2혹p53단일고표체자,역저우량자균쌍저f표체자.결론 COX-2화p53적표체여림상분기、림파결전이、원처전이、병리분급등림상예후불량인소유관.검측COX-2화p53대유선암적예후유중요개치.
Objective To detect the expression of COX-2 and p53 in breast carcinoma tissue and investigate their associations with clinical prognosis.Methods The expression of COX-2 and p53 was carried out in 16 cases of normal epithelial tissue and 152 cases of breast carcinoma tissue using immunohistochemistry SP method.The correlation of their expression with clinical characteristics was analyzed using SPSS software 16.0.Survival analysis was used to investigate their effects on tumor prognosis.Results No positive COX-2and p53 expressions were observed in normal epithelial tissue.Among 152 patients,89 (58.6 ％) were positive staining rete for COX-2 and 93 (61.18 ％) were shown p53 expression, with a statistically significant associations between expressions of COX-2 and p53 and breast cancer (r =0.426,P ＜ 0.01).The COX-2 and p53 expressions were significantly correlated with pathological grade, clinical stage, lymph node or distant organ metastasis.There was a statistically significant correlation between COX-2 and p53 expression and pathological grade Ⅰ / Ⅱ.The 5-year progress-free survival (PFS) rate in patients with COX-2 over-expression was 61.3 ％, which was remarkably lower than that in those with low COX-2 expression.There was no statistically significant difference of 5-year PFS between positive and negative p53 expression.A shorter 5-year PFS was seen in patients with co-expression of COX-2 and p53 than in those with either COX-2 or p53positive expression alone and also than in those with both COX-2 and p53 negative expression.Conclusion Detection of the expressions of COX-2 and p53 can be used to predict the prognosis of breast cancer.
