CAJ | 학술논문

我们先前通过全基因组扫描发现1p36与体重指数显提示性连锁(LOD=2.09).肿瘤坏死因子受体2(TNFR2)定位于1p36,是肥胖的一个极好的图位和功能侯选基因.本研究采用数量传递连锁不平衡检验在两个大的独立的白人样本中进行了TNFR2基因与肥胖表型的连锁与关联检验.第一组受试者由来自79个多代家系的1 836个个体组成;第二组受试者由来自157个核心家庭的636个个体组成.所检测的肥胖表型包括体重指数、脂肪量和脂肪量百分数.在多代家系中我们发现TNFR2基因变异与BMI显著连锁(P=0.0056).结果表明,TNFR2基因是影响白人BMI变异的一个数量性状位点.
아문선전통과전기인조소묘발현1p36여체중지수현제시성련쇄(LOD=2.09).종류배사인자수체2(TNFR2)정위우1p36,시비반적일개겁호적도위화공능후선기인.본연구채용수량전체련쇄불평형검험재량개대적독립적백인양본중진행료TNFR2기인여비반표형적련쇄여관련검험.제일조수시자유래자79개다대가계적1 836개개체조성;제이조수시자유래자157개핵심가정적636개개체조성.소검측적비반표형포괄체중지수、지방량화지방량백분수.재다대가계중아문발현TNFR2기인변이여BMI현저련쇄(P=0.0056).결과표명,TNFR2기인시영향백인BMI변이적일개수량성상위점.
Previously, our group has reported a suggestive linkage evidence of 1p36 with body mass index (BMI) (LOD =2.09).The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is an excellent positional and functional candidate gene for obesity. In this study, we have investigated the linkage and association between the TNFR2 gene and obesity phenotypes in two large independent samples, using the quantitative transmission disequilibrium tests (QTDT). The first group was made up of 1 836 individuals from 79 multi-generation pedigrees. The second group was a randomly ascertained set of 636 individuals from 157 US Caucasian nuclear families. Obesity phenotypes tested include BMI, fat mass, and percentage fat mass (PFM). A significant result (P = 0.0056) was observed for linkage with BMI in the sample of the multigenerational pedigrees. Our data support the TNFR2 gene as a quantitative trait locus (QTL) underlying BMI variation in the Caucasian populations.