CAJ | 학술논문

巨细胞移动抑制因子(MIF)是一种在体外能抑制巨噬细胞移动的物质。现已发现MIF在类风湿性关节炎(RA)、动脉粥样硬化(AS)和系统性红斑狼疮(SLE)等急性和慢性免疫炎症情况中具有关键的调节作用。这些疾病的共同特征是损伤部位有免疫细胞的浸润和活化。在这些疾病中起作用的炎症过程相互重叠，并观察到AS是RA、SLE的一种主要伴随疾病，这使MIF可以成为治疗这些疾病的一个极有希望的候选靶点。MIF和糖皮质激素(GC)之间独特的关系突显了MIF可以作为一种“类固醇减量”疗法治疗这些疾病的一个潜在性靶点。
거세포이동억제인자(MIF)시일충재체외능억제거서세포이동적물질。현이발현MIF재류풍습성관절염(RA)、동맥죽양경화(AS)화계통성홍반랑창(SLE)등급성화만성면역염증정황중구유관건적조절작용。저사질병적공동특정시손상부위유면역세포적침윤화활화。재저사질병중기작용적염증과정상호중첩，병관찰도AS시RA、SLE적일충주요반수질병，저사MIF가이성위치료저사질병적일개겁유희망적후선파점。MIF화당피질격소(GC)지간독특적관계돌현료MIF가이작위일충“류고순감량”요법치료저사질병적일개잠재성파점。
As an in vitro inhibitor of macrophage migration, macrophage migration inhibitory factor (MIF)was originally discovered and named. It has now been shown that this cytokine has regulatory role in acute and chronic immunoinflammatory diseases including rheumatoid arthritis(RA), atherosclerosis(AS)and systemic lupus erythematosus(SLE). Common characteristic events in these diseases are the activation and infiltration of immune cells at the site of injury. The overlap of inflammatory processes operating in these diseases and the observation of atherosclerosis as a major comorbidity of RA and SLE make MIF a greatly hopeful candidate for therapeutic targeting in these diseases. Moreover, the unique relationship between MIF and glucocorticoids highlights the potential role of MIF as a‘ steroid sparing' therapeutic target including all these conditions.