CAJ | 학술논문

目前在全球呈现大流行趋势的甲型H1N1流感病毒是具备高度传染性的病毒,儿童和年轻成年人是主要易患人群,其临床表现相对轻微,但仍有部分病例因出现严重并发症而需要住院治疗.儿童,尤其是小于5岁者,是此次甲型H1N1流感流行中较易成为重症病例的高危人群,容易发生严重并发症,尤其是伴有慢性呼吸道、心血管疾病及免疫缺陷的儿童可能面临更大的死亡危险.神经氨酸酶抑制剂奥司他韦和扎那米韦是目前推荐使用的用于预防和治疗的抗病毒药物.疫苗被认为是控制流行的有效手段.
목전재전구정현대류행추세적갑형H1N1류감병독시구비고도전염성적병독,인동화년경성년인시주요역환인군,기림상표현상대경미,단잉유부분병례인출현엄중병발증이수요주원치료.인동,우기시소우5세자,시차차갑형H1N1류감류행중교역성위중증병례적고위인군,용역발생엄중병발증,우기시반유만성호흡도、심혈관질병급면역결함적인동가능면림경대적사망위험.신경안산매억제제오사타위화찰나미위시목전추천사용적용우예방화치료적항병독약물.역묘피인위시공제류행적유효수단.
Human swine influenza A (H1N1) is a highly transmissible infectious disease, which has spreaded globally and represented a continuous pandemic threat. The novel virus has predominantly affected the children and young adults. Clinical manifestations generally appear mild, but there are still many patients with severe complications leading to hospitalization. According to the current reports, the mortality in the early stages of the pandemic appears no more than seasonal influenza A . Children (especially less than 5years) are considered to be at higher risk of infection and complications. Pediatric patients with a underlying significant chronic disease such as chronic respiratory disease,cardiovascular disease and immunodeficiency disease, are at a higher risk of death. The neuraminidase inhibitors Oseltamivir and Zanamivir are effective for prophylaxis and treatment. Effective vaccines are regarded to be crucial for the control of influenza pandemics. This review focuses on the epidemiological situation, clinical characteristics and management of human swine influenza A (H1N1), so as to provide practical advice for clinicians.