CAJ | 학술논문

脑性瘫痪(脑瘫)是导致小儿神经系统伤残的主要疾病.脑瘫发病过程复杂,是多因素综合作用的结果,而目前尚未有获得公认的脑瘫动物模型.该文总结了近期国内外不同脑瘫动物模型:缺血缺氧因素、感染因素、高胆红素因素,并对不同模型之间的有效性进行了比较.其中缺血缺氧因素是目前应用及研究最多的因素,其他两个因素的研究尚处于萌芽阶段,有待于进一步地发展.
뇌성탄탄(뇌탄)시도치소인신경계통상잔적주요질병.뇌탄발병과정복잡,시다인소종합작용적결과,이목전상미유획득공인적뇌탄동물모형.해문총결료근기국내외불동뇌탄동물모형:결혈결양인소、감염인소、고담홍소인소,병대불동모형지간적유효성진행료비교.기중결혈결양인소시목전응용급연구최다적인소,기타량개인소적연구상처우맹아계단,유대우진일보지발전.
Cerebral palsy(CP)is one of the main diseases which induce the invalids of children nervous system.The pathogenesis of CP iS fairly complex,which correlates with many factors.At present,there is no one kind of animal odel of CP that can be received by the public.To solve this problem,this review summarizes the most up-to-date three models which relate to the pathogenesis,ischemia and hypoxia model,infection model and hyperbilirubin model,and compares their different validities,eventually brings forward the common effective criterions to identiticare different models.Among these three models,the ischemia and hypoxia model is the most popular application and research objection,the two others are sprouting on their way waiting further develpoment.