CAJ | 학술논문

目的观察2型糖尿病(T2DM)并肥胖患者血清白细胞介素-18(IL-18)水平与淋巴细胞亚群的变化.方法 64例T2DM患者按是否伴有肥胖分为糖尿病并肥胖患者31例(A组)、糖尿病不伴有肥胖33例(B组),选择同期健康体检者23例(C组),观察各组血糖(FPG)、胰岛素(FPI)、总胆固醇(TC)、甘油三酯(TG)、IL-18和外周血中T淋巴细胞亚群CD3+及CD4+、CD8+的变化及胰岛素敏感指数(ISI)不同.结果与C组比较,A组、B组的TC、TG、FPG、FPI水平均明显增高(P＜0.05、P＜0.01),ISI则显著降低(P＜0.01);与B组比较,A组的血脂显著增高(P＜0.05);与C组比较,A组、B组的CD3+、CD8+亚群细胞数、IL-18水平均显著增高(P＜0.05,P＜0.01),CD4+、CD4+/CD8+比值显著降低(P＜0.05);与B组比较,A组CD3+、CD8+亚群细胞数均显著增高(P＜0.05),CD4+、CD4+/CD8+比值显著降低(P＜0.05).结论 T2DM患者胰岛素抵抗、脂代谢紊乱、免疫功能紊乱与肥胖有关.
목적 관찰2형당뇨병(T2DM)병비반환자혈청백세포개소-18(IL-18)수평여림파세포아군적변화.방법 64례T2DM환자안시부반유비반분위당뇨병병비반환자31례(A조)、당뇨병불반유비반33례(B조),선택동기건강체검자23례(C조),관찰각조혈당(FPG)、이도소(FPI)、총담고순(TC)、감유삼지(TG)、IL-18화외주혈중T림파세포아군CD3+급CD4+、CD8+적변화급이도소민감지수(ISI)불동.결과 여C조비교,A조、B조적TC、TG、FPG、FPI수평균명현증고(P＜0.05、P＜0.01),ISI칙현저강저(P＜0.01);여B조비교,A조적혈지현저증고(P＜0.05);여C조비교,A조、B조적CD3+、CD8+아군세포수、IL-18수평균현저증고(P＜0.05,P＜0.01),CD4+、CD4+/CD8+비치현저강저(P＜0.05);여B조비교,A조CD3+、CD8+아군세포수균현저증고(P＜0.05),CD4+、CD4+/CD8+비치현저강저(P＜0.05).결론 T2DM환자이도소저항、지대사문란、면역공능문란여비반유관.
Objective To observe on the variance of serum IL-18 level and lymphocyte subpopulations in the patients with obese diabetic(T2DM).Methods The diabetic obese group contained 31 cases,the non-diabetic obese group contained 33 cases,healthy normal body weight group contained 23 cases,the blood glucose(FPG),insulin (FPI),blood total cholesterol(TC),triglyceride(TG),IL-18 and the cell population of lymphocyte subpopulations CD3+and CD4+、CD8+ in peripheral blood were determined,the insulin sensitivity index were calcnlated.Results Compared with the healthy normal body weight group,the blood fat,FPG,FPI,IL-18 of T2DM patients significantly increased,there were significant statistical difference(P ＜ 0.05 or P ＜ 0.01).The ISI significantly decreased(P ＜ 0.01).Compared with the non-diabetic obese group,the blood fat and IL-18 of T2DM patients significantly increased (P＜0.05).Compared with the diabetic obese group,the subpopulations cell population of CD3+、CD4+、CD8+ in the non-diabetic obese group significantly decreased,the ratio of CD4+/CD8+ significantly increased,there were significant statistical difference(P＜0.05 or P＜0.01)in the two groups comparison.Compared with the non-diabetic obese CD4+/CD8+ significantly increased(P＜0.05).Conclusion T2DM patients should prevent the hyperinsulinemia,control blood sugar,reduce insulin resistance,sustain normal lipid metabolism,boost immune function.