CAJ | 학술논문

肠促胰素是肠道在进餐后分泌的激素,能促进胰岛素的分泌.胰高糖素样肽1(GLP-1)是主要的肠促胰素,通过葡萄糖依赖的方式促进胰岛素分泌、抑制胰高糖素分泌以及延缓胃排空、增加饱腹感等作用维持体内血糖的稳定.另外,在2型糖尿病患者中,它还可改善β细胞功能.但是天然的GLP-1半寿期很短,无法用于临床治疗.艾塞那肽是从希拉巨蜥唾液中分离得到的一种多肽,它可与GLP-1受体结合,产生与GLP-1相似的生理效应,但它的半寿期远比GLP-1长,因此每天两次皮下注射即可产生满意的疗效.临床研究显示艾塞那肽可显著降低2型糖尿病患者HbA_(1C)、空腹血糖及餐后血糖,并降低体重.动物研究表明艾塞那肽还可改善β细胞功能、增加β细胞量.由于GLP-1受体激动剂的独特疗效,新近的糖尿病治疗指南已将其列入2型糖尿病的治疗药物.
장촉이소시장도재진찬후분비적격소,능촉진이도소적분비.이고당소양태1(GLP-1)시주요적장촉이소,통과포도당의뢰적방식촉진이도소분비、억제이고당소분비이급연완위배공、증가포복감등작용유지체내혈당적은정.령외,재2형당뇨병환자중,타환가개선β세포공능.단시천연적GLP-1반수기흔단,무법용우림상치료.애새나태시종희랍거석타액중분리득도적일충다태,타가여GLP-1수체결합,산생여GLP-1상사적생리효응,단타적반수기원비GLP-1장,인차매천량차피하주사즉가산생만의적료효.림상연구현시애새나태가현저강저2형당뇨병환자HbA_(1C)、공복혈당급찬후혈당,병강저체중.동물연구표명애새나태환가개선β세포공능、증가β세포량.유우GLP-1수체격동제적독특료효,신근적당뇨병치료지남이장기렬입2형당뇨병적치료약물.
Incretins ale gut hormones,which stimulate insulin secretion after meal.One of the incretin hormones,glucagon-like peptide-1(GLP-1),contributes to glucose homeostasis by stimulation of insulin secretion,suppression of glucagon secretion(both in a glucose dependent manner),slowing of gastric emptying,and induction of satiety.It could also improve beta cell function in type 2 diabetes.However,due to its short biological half-life,GLP-1 itself is not practical for type 2 diabetes therapy.Exenatide is a peptide found in the lizard Heloderma suspectum and has a high similarity to GLP-1.It has a much longer biological half life than GLP-1 and is a GLP-1 receptor agonist that Can be used for therapeutic purposes by twice daily injection.Clinical studies with exenatide have shown a significant reduction in HbA_(1C),fasting and postprandial glucose,and body weight in type 2 diabetic patients.Animal studies revealed an improvement of beta cell funotion and an increase in beta cell mass after exenatide treatment.Due to its special therapeutic efficacy,GLP-1 receptor agonist,such as exenatide,is now included in the recently published guidelines for the treatment of type 2 diabetes mellitus.