CAJ | 학술논문

非编码RNA是指除mRNA、tRNA和rRNA以外,不编码蛋白质的RNA分子.它们在细菌、真菌和哺乳动物等许多生物体的重要生命活动中发挥着极广泛的调控作用.近年来研究表明,非编码RNA既可作为癌基因,也可作为抑癌基因,对肿瘤的发生、发展产生重大的影响.同时,非编码RNA又有希望成为肿瘤诊断的标志物和肿瘤治疗的新靶点.作者综述了小干扰RNA和微小RNA等主要非编码RNA与肿瘤关系的最新研究进展.
비편마RNA시지제mRNA、tRNA화rRNA이외,불편마단백질적RNA분자.타문재세균、진균화포유동물등허다생물체적중요생명활동중발휘착겁엄범적조공작용.근년래연구표명,비편마RNA기가작위암기인,야가작위억암기인,대종류적발생、발전산생중대적영향.동시,비편마RNA우유희망성위종류진단적표지물화종류치료적신파점.작자종술료소간우RNA화미소RNA등주요비편마RNA여종류관계적최신연구진전.
Non-coding RNAs (ncRNAs) are RNA molecules that exclude mRNA, tRNA and rRNA,and do not code proteins. ncRNAs play a various roles in the regulation of important vital activities in many organisms such as bacteria, fungi and mammals. Recent researches have shown that ncRNAs, as oncogenes or tumor suppressor genes, have tremendous impacts on the occurrence and development of tumors. Meanwhile, ncRNAs have become a new type of tumor markers and new targets for cancer treatment. This review describes the research progresses of ncRNAs such as small interference RNA and microRNA, and their roles in carcinogenesis.