CAJ | 학술논문

目的观察术前化疗联合外科手术治疗对小细胞肺癌(SCLC)长期生存的影响.方法总结北京市结核病胸部肿瘤研究所1994年1月至2005年1月手术切除的263例SCLC的综合治疗效果.比较术前化疗组(A组,n=111例)和术后化疗组(B组,n=96例)的治疗效果.结果全组5年生存率42.16%.A组5年生存率38.25%,B组5年生存46.57%.A组5年生存率Ⅰ期60.15%、Ⅱ期35.70%、Ⅲ<,a>期40.16%、Ⅲ<,b>期14.29%、Ⅳ期0,A组5年生存率NO-1和N2为40.12%和39.22%.B组5年生存率Ⅰ期61.10%、Ⅱ期50.23%、Ⅲa期42.32%、Ⅲb期26.47%、Ⅳ期0,B组5年生存率NO-1和N2组为51.91%和42.69%.结论术前化疗病例比术后化疗病例有预后变差倾向;SCLC要取得较好的治疗效果,手术+术后化疗模式不可缺少.
목적 관찰술전화료연합외과수술치료대소세포폐암(SCLC)장기생존적영향.방법 총결북경시결핵병흉부종류연구소1994년1월지2005년1월수술절제적263례SCLC적종합치료효과.비교술전화료조(A조,n=111례)화술후화료조(B조,n=96례)적치료효과.결과 전조5년생존솔42.16%.A조5년생존솔38.25%,B조5년생존46.57%.A조5년생존솔Ⅰ기60.15%、Ⅱ기35.70%、Ⅲ<,a>기40.16%、Ⅲ<,b>기14.29%、Ⅳ기0,A조5년생존솔NO-1화N2위40.12%화39.22%.B조5년생존솔Ⅰ기61.10%、Ⅱ기50.23%、Ⅲa기42.32%、Ⅲb기26.47%、Ⅳ기0,B조5년생존솔NO-1화N2조위51.91%화42.69%.결론 술전화료병례비술후화료병례유예후변차경향;SCLC요취득교호적치료효과,수술+술후화료모식불가결소.
Objective To reveal the pre-operative chemotherapy for long-term of small cell lung cancer. Methods From January 1994 to January 2005, 263 patients with small cell lung cancer underwent combined therapy. The comparison of long-term survival rates was made between pre-operative chemotherapy group (n = 111) (group A) and post-operative chemotherapy (n = 96) (group B). Results The analyses disclosed that the overall 5-year survival rate was 42. 16%. The 5-year survival rate of group A was 38. 25% while in group B it was 46. 57%. 5-year survival rate of group A for NO-1 and N2 was 40. 12% and 39.22%, that for stage Ⅱ , Ⅱ, Ⅲ ,Ⅲ<,b>, Ⅳ was 60.15%, 35.70%, 40.16%, 14.29% and 0 respectively. 5-year survival rate of group B for NO-1 and N<,2> was 51.91% and 42.69%, that for stage Ⅰ , Ⅱ,Ⅲa, Ⅲb, Ⅳ was 61.1%, 50.23%, 42.32%, 26.47% and 0 respectively. Conclusion The comparison of the survival rate between patients with the pre-operative chemotherapy and those with chemotherapy post-operatively revealed trend of variation. Operation plus post-operative chemotherapy mode is indispensable for better prognosis of small cell lung cancer.