CAJ | 학술논문

目的探讨细胞因子白细胞介素-6（IL-6）和肿瘤坏死因子（TNF）与骨质疏松发生的关系。方法以去势后雌性SD大鼠为模型，分去势组、假手术组和去势加利维爱组，共三组，对照研究骨密度（BMD）和骨髓微环境中IL-6和TNF的含量变化。结果骨髓单核细胞具有分泌TNF和IL-6作用；卵巢分泌性激素水平下降可导致骨髓单核细胞TNF和IL-6基因表达调节失控；去势后大鼠体内TNF和IL-6水平与BMD呈负相关。结论提示TNF和IL-6的水平升高是引起骨丢失的机理之一，卵巢分泌性激素对TNF和IL-6具有下调作用。
목적탐토세포인자백세포개소-6（IL-6）화종류배사인자（TNF）여골질소송발생적관계。방법이거세후자성SD대서위모형，분거세조、가수술조화거세가리유애조，공삼조，대조연구골밀도（BMD）화골수미배경중IL-6화TNF적함량변화。결과골수단핵세포구유분비TNF화IL-6작용；란소분비성격소수평하강가도치골수단핵세포TNF화IL-6기인표체조절실공；거세후대서체내TNF화IL-6수평여BMD정부상관。결론제시TNF화IL-6적수평승고시인기골주실적궤리지일，란소분비성격소대TNF화IL-6구유하조작용。
Objective　To study the relation between cytokines and osteoporosis．Methods　In the present study the changes of bone mineral density （BMD）and interleukin-6（IL-6），tumor necrosis factor （TNF）concentration in bone marrow microenvironment were observed．We used ovariected female SD rats as osteoporosis model．The rats were randomly divided into three groups：ovariectomy （OVX），Sham-operation （Sham），OVX＋Livial．Results　1．Bone marrow monocytes （BMM） secreted TNF，IL-6；2．The abnormal gene expression of TNF，IL-6 in BMM was resulted from the reduction in estrogen secreted by ovaries．Conclusion　The increase of TNF，IL-6 concentration may be one of the pathogenesis of bone loss．Estrogen secreted by ovaries reduces TNF，IL-6 secretion in bone marrow microenvironment．