CAJ | 학술논문

目的:探讨强化胰岛素治疗对脓毒症病人D-乳酸和二胺氧化酶(DAO)的影响,观察胰岛素对脓毒症病人肠黏膜通透性的作用.方法: 将48例脓毒症病人随机分为治疗组和对照组.治疗组病人用胰岛素治疗,血糖严格控制在5.0～7.0 mmol/L.对照组病人常规治疗,血糖控制在10.0～11.9 mmol/L.于治疗前后检测血浆D-乳酸含量和DAO活性. 结果: 治疗后治疗组病人血浆D-乳酸水平和DAO活性明显低于对照组(P<0.05).结论: 胰岛素能降低脓毒症病人肠道黏膜通透性,减少肠道细菌移位,改善肠功能障碍.
목적:탐토강화이도소치료대농독증병인D-유산화이알양화매(DAO)적영향,관찰이도소대농독증병인장점막통투성적작용.방법: 장48례농독증병인수궤분위치료조화대조조.치료조병인용이도소치료,혈당엄격공제재5.0～7.0 mmol/L.대조조병인상규치료,혈당공제재10.0～11.9 mmol/L.우치료전후검측혈장D-유산함량화DAO활성. 결과: 치료후치료조병인혈장D-유산수평화DAO활성명현저우대조조(P<0.05).결론: 이도소능강저농독증병인장도점막통투성,감소장도세균이위,개선장공능장애.
Objective: To discuss the effect of intensive insulin therapy on D-lactic acid and diamine oxidase level in patients with sepsis.Methods: 48 patients was divided into control group and conventional group randomly.Content of D-lactic acid and diamine oxidase in serum was detected with absorption spectrometry before and after therapy.Result: D-lactic acid and diamine oxidase in patients decreased significantly in control group compared to that of conventional group.Conclusion: Insulin can depress interstinal permeability and ameliorate sepsis symptom resulted from bacterial translocation from intestine.