国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2008年
10期
780-783
,共4页
肝细胞生长因子%受体蛋白质酪氨酸激酶类%肝肿瘤%胆管肿瘤
肝細胞生長因子%受體蛋白質酪氨痠激酶類%肝腫瘤%膽管腫瘤
간세포생장인자%수체단백질락안산격매류%간종류%담관종류
Hepatocyte growth factor%Receptor protein-tyrosine kinases%Liver neoplasms%Bile duct neoplasms
肝细胞生长因子及其受体(HGF/c-Met)通路的过度激活在肿瘤的演进过程中起到非常重要的作用.研究证实HGF/c-Met在肝癌及胆管癌中呈高表达,直接或间接参与肿瘤的发生、侵袭和转移过程,且与预后有重要关系.近年来,针对该通路抑制剂的研发已成为抗肿瘤药物的研究热点.
肝細胞生長因子及其受體(HGF/c-Met)通路的過度激活在腫瘤的縯進過程中起到非常重要的作用.研究證實HGF/c-Met在肝癌及膽管癌中呈高錶達,直接或間接參與腫瘤的髮生、侵襲和轉移過程,且與預後有重要關繫.近年來,針對該通路抑製劑的研髮已成為抗腫瘤藥物的研究熱點.
간세포생장인자급기수체(HGF/c-Met)통로적과도격활재종류적연진과정중기도비상중요적작용.연구증실HGF/c-Met재간암급담관암중정고표체,직접혹간접삼여종류적발생、침습화전이과정,차여예후유중요관계.근년래,침대해통로억제제적연발이성위항종류약물적연구열점.
Over-activation of HGF/c-Met plays an important role in the evolution process of tumor. It has been demonstrated HGF/c-Met is overexpressed in hepatocellular carcinoma and cholangiocarcinoma, and it participates directly or indirectly in the progress of tumor genesis, invasion and metastasis, as well as has significantly correlation with prognosis. Recently, blocking HGF/c-Met pathway to prevent tumor development and metastasis has become a focus in anti-tumor studies.
