CAJ | 학술논문

MicroRNA是一类在转录后水平上调控基因表达的内源性非编码小分子RNA.microRNA参与了固有免疫和适应性免疫的相关过程,在调节TLR信号通路,抗病毒免疫以及B细胞、T细胞发育和功能等多种免疫活动中发挥着重要的作用.一方面机体可以通过编码microBNA来调节在机体免疫细胞发育与分化及免疫系统功能方面发挥重要作用的基因,从而精细调节细胞对外界影响的反应,另一方面宿主细胞可通过编码microRNA来控制病原体基因的表达,从而干扰其发展,而病原体则反过来利用自身的microRNA或控制宿主microRNA的表达,进而逃避免疫系统的清除.对microRNA在免疫系统中作用的研究将有助于更清楚的认识免疫系统的作用机制,从而为靶向药物的研制以及人类疾病的防治提供一条新途径.
MicroRNA시일류재전록후수평상조공기인표체적내원성비편마소분자RNA.microRNA삼여료고유면역화괄응성면역적상관과정,재조절TLR신호통로,항병독면역이급B세포、T세포발육화공능등다충면역활동중발휘착중요적작용.일방면궤체가이통과편마microBNA래조절재궤체면역세포발육여분화급면역계통공능방면발휘중요작용적기인,종이정세조절세포대외계영향적반응,령일방면숙주세포가통과편마microRNA래공제병원체기인적표체,종이간우기발전,이병원체칙반과래이용자신적microRNA혹공제숙주microRNA적표체,진이도피면역계통적청제.대microRNA재면역계통중작용적연구장유조우경청초적인식면역계통적작용궤제,종이위파향약물적연제이급인류질병적방치제공일조신도경.
MicroRNAs are an endogenous class of small non-protein-coding RNAs that can regulate gene expression at the post-transcriptional levels. The recent studies demonstrate that microRNAs play an important role in regulating the development of immune cells and in modulating innate and adaptive immune responses such as signaling of TLRs, immunity of anti-virus, and development and function of T cells and B cells. MicroRNAs can guide the RNA-induced silencing complex to cognate target genes and repress target gene expression by either destabilizing target mRNAs or repressing their translation. MicroRNAs can also inhibit pathogen' s gene expression for immune defence. Research on the relationship between microRNAs and immune system will give us a better understanding of the mechanisms of immune response and in the future developing of novel therapeutics to target microRNAs. Which modulate immune responses.