CAJ | 학술논문

儿童生长发育是一个复杂的过程,受到众多因素的影响,目前研究认为芳香化酶是影响因素之一.芳香化酶由CYP19A1基因编码,能催化雄激素转变为雌激素.有研究显示CYP19A1多态性变异部分是导致身高差异的基因学机制,芳香化酶相关基因多态性与青春发育亦有关联.该文主要综述芳香化酶及其相关基因的结构和功能、与青春发育的关系、基因缺陷所导致的青春发育异常,探讨儿童生长发育异常的发病机制.
인동생장발육시일개복잡적과정,수도음다인소적영향,목전연구인위방향화매시영향인소지일.방향화매유CYP19A1기인편마,능최화웅격소전변위자격소.유연구현시CYP19A1다태성변이부분시도치신고차이적기인학궤제,방향화매상관기인다태성여청춘발육역유관련.해문주요종술방향화매급기상관기인적결구화공능、여청춘발육적관계、기인결함소도치적청춘발육이상,탐토인동생장발육이상적발병궤제.
Growth and development in children comprises a complex interaction of factors. More recently, it was reported that aromatase P450 may play an important role in growth and development. Aromatase is encoded by CYP19A1 gene,catalyzes the conversion of androgens to estrogens. Research data indicated that CYP 19A1 gene polymorphisms may partly influence adult height in healthy subjects. Also previous study reported the association between aromatase-related genes polymorphisms and early puberty in human. This review summarizes structure and function of aromatase-related genes,their association with puberty, abnormal puberty onset due to gene defects. There is a focus on the pathogenesis underlying growth and development in children.