CAJ | 학술논문

目的探讨自体角膜缘干细胞移植治疗较小角膜皮样瘤的可行性.方法前瞻性研究.将34例角膜皮样瘤患者按完全随机对照方法分成A组(肿瘤切除联合自体角膜缘干细胞移植术)；B组(肿瘤切除联合异体板层角膜移植术).观察患者术后经过、肿瘤复发、以及视力、屈光度、散光度等情况.结果 A、B两组术后均未出现肿瘤复发,治愈率100％.A、B两组术后早期均有不同程度的角膜上皮糜烂,1月后角膜上皮基本愈合.A组2年后遗留不同程度的角膜翳,但未见新生血管进入角膜；B组术后外观改善良好,13例患者移植片透明.术后早期2例患者出现轻度层间混浊,新生血管到达角膜缘,3例患者出现层间新生血管,这5只眼治疗后,移植片透明.A、B两组术后裸眼视力、最佳矫正视力、屈光度、散光度差异无统计学意义(P＞0.05).结论肿瘤切除联合自体角膜缘干细胞移植术对较小的角膜皮样瘤的疗效等同于异体板层角膜移植术,且该术式取材方便,手术简单,是一种安全可行的治疗方法.
목적 탐토자체각막연간세포이식치료교소각막피양류적가행성.방법 전첨성연구.장34례각막피양류환자안완전수궤대조방법분성A조(종류절제연합자체각막연간세포이식술)；B조(종류절제연합이체판층각막이식술).관찰환자술후경과、종류복발、이급시력、굴광도、산광도등정황.결과 A、B량조술후균미출현종류복발,치유솔100％.A、B량조술후조기균유불동정도적각막상피미란,1월후각막상피기본유합.A조2년후유류불동정도적각막예,단미견신생혈관진입각막；B조술후외관개선량호,13례환자이식편투명.술후조기2례환자출현경도층간혼탁,신생혈관도체각막연,3례환자출현층간신생혈관,저5지안치료후,이식편투명.A、B량조술후라안시력、최가교정시력、굴광도、산광도차이무통계학의의(P＞0.05).결론 종류절제연합자체각막연간세포이식술대교소적각막피양류적료효등동우이체판층각막이식술,차해술식취재방편,수술간단,시일충안전가행적치료방법.
Objective To discuss the feasibility analysis of tumor excision along with limbal stem cell transplantation for smaller range of comeal dermoid tumor.Methods Prospective study:The 34 corneal dermoid patients whom met the criteria were randomly divided into control group A (took limbal stem cell transplantation) and group B (took allogeneic lamellar keratoplasty).Afterwards,patients' visual acuity,dioptre,cylinder and other indicators of clinical efficacy were observed. Results Group A and B had no significant difference in efficacy of best corrected visual acuity dioptre and cylinder.And both group A and B had no significant complications. Conclusions The efficacy of resection combined with autologous limbal stem cell transplantation for the smaller range of comeal dermoid are equal to the allogeneic lamellar keratoplasty,but the former is simpler in operation and has very few medical rejection.Its postoperative medication is also simple.Therefore,it is a safe and feasible surgical method.