中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
4期
470-473
,共4页
基质金属蛋白酶类/代谢%血管内皮生长因子C/代谢%乳腺肿瘤/代谢
基質金屬蛋白酶類/代謝%血管內皮生長因子C/代謝%乳腺腫瘤/代謝
기질금속단백매류/대사%혈관내피생장인자C/대사%유선종류/대사
Matrix metalloproteinases/ME%Vascular endothelial growth factor C/ME%Breast neoplasms/ME
目的 研究细胞外基质金属蛋白酶诱导因子(EMMPRIN)和血管内皮生成因子-C(VEGF-C)蛋白表达与乳腺癌浸润和转移之间的关系.方法 免疫组化法检测乳腺增生组21例、导管内癌组10例、浸润性导管癌组68例病灶内EMMPRIN和VEGF-C蛋白的表达情况.结果 EMMPRIN蛋白在增生组、导管内癌组、浸润性导管癌组表达阳性率分别为4.76%(1/21)、40.00%(4/10)73.53%(50/68),3组之间的阳性率差异均有统计学意义(P<0.01).VEGF-C蛋白在增生组、导管内癌组、浸润性导管癌组表达阳性率分别为14.29%(3/21)、60.00(6/10)、77.94%(53/68),导管内癌组和浸润性导管癌组阳性率明显高于增生组(P<0.01).乳腺癌组织中EMMPRIN和VEGF-C的表达呈正相关(rs=0.390,P<0.01),而且EMMPRIN和VEGF-C的表达与腋窝淋巴结转移及淋巴结转移数目有关(P<0.01).结论 EMMPRIN和VEGF-C的过度表达是促进乳腺癌浸润和转移的重要因素,二者在乳腺癌的浸润和转移过程中可能起着协同作用.
目的 研究細胞外基質金屬蛋白酶誘導因子(EMMPRIN)和血管內皮生成因子-C(VEGF-C)蛋白錶達與乳腺癌浸潤和轉移之間的關繫.方法 免疫組化法檢測乳腺增生組21例、導管內癌組10例、浸潤性導管癌組68例病竈內EMMPRIN和VEGF-C蛋白的錶達情況.結果 EMMPRIN蛋白在增生組、導管內癌組、浸潤性導管癌組錶達暘性率分彆為4.76%(1/21)、40.00%(4/10)73.53%(50/68),3組之間的暘性率差異均有統計學意義(P<0.01).VEGF-C蛋白在增生組、導管內癌組、浸潤性導管癌組錶達暘性率分彆為14.29%(3/21)、60.00(6/10)、77.94%(53/68),導管內癌組和浸潤性導管癌組暘性率明顯高于增生組(P<0.01).乳腺癌組織中EMMPRIN和VEGF-C的錶達呈正相關(rs=0.390,P<0.01),而且EMMPRIN和VEGF-C的錶達與腋窩淋巴結轉移及淋巴結轉移數目有關(P<0.01).結論 EMMPRIN和VEGF-C的過度錶達是促進乳腺癌浸潤和轉移的重要因素,二者在乳腺癌的浸潤和轉移過程中可能起著協同作用.
목적 연구세포외기질금속단백매유도인자(EMMPRIN)화혈관내피생성인자-C(VEGF-C)단백표체여유선암침윤화전이지간적관계.방법 면역조화법검측유선증생조21례、도관내암조10례、침윤성도관암조68례병조내EMMPRIN화VEGF-C단백적표체정황.결과 EMMPRIN단백재증생조、도관내암조、침윤성도관암조표체양성솔분별위4.76%(1/21)、40.00%(4/10)73.53%(50/68),3조지간적양성솔차이균유통계학의의(P<0.01).VEGF-C단백재증생조、도관내암조、침윤성도관암조표체양성솔분별위14.29%(3/21)、60.00(6/10)、77.94%(53/68),도관내암조화침윤성도관암조양성솔명현고우증생조(P<0.01).유선암조직중EMMPRIN화VEGF-C적표체정정상관(rs=0.390,P<0.01),이차EMMPRIN화VEGF-C적표체여액와림파결전이급림파결전이수목유관(P<0.01).결론 EMMPRIN화VEGF-C적과도표체시촉진유선암침윤화전이적중요인소,이자재유선암적침윤화전이과정중가능기착협동작용.
Objective To study the correlation of EMMPRIN and VEGF-C expression with invasion and metastasis of breast carcinoma. Method The expression of EMMPRIN and VEGF-C was detected by immunohistochemical technique in 21 cases hyperplasia of mammary glands, 10 cases of in-tubule carcinoma and 68 cases invasive carcinoma. Results The positive rate of EMMPRIN expression in hyperplasia of mammary glands, in-tubule carcinoma and invasive carcinoma were 4. 76% (1/21), 40. 00% (4/10)73.53% (50/68), respectively;Significant difference was found among three groups ( P < 0.01 ). The positive rate of VEGF-C expression in hyperplasia, in-tubule carcinoma and invasive carcinoma were14. 29% (3/21) ,60. 00 (6/10) ,77.94% (53/68), respectively. The positive rates of VEGF-C expression in situ and invasive ductal carcinoma were remarkably higher than that of hyperplasia of mammary glands ( P <0. 01 ). The expression of EMMPRIN significantly correlated with the expression of VEGF-C in breast tubule carcinoma ( rs =0. 390, P <0. 01 ), Lymph nod metastasis and the number axillary Lymph nod metastasis were related to EMMPRIN and VEGF-C ( P < 0. 01 ). Conclusion The over-expression of EMMPRIN and VEGF-C were important elements to promote the invasiveness and metastasis of breast carcinoma. Synergistic effect between EMMPRIN and VEGF-C may take place in lymph node metastasis of breast carcinoma.
