国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
15期
1815-1818
,共4页
肺表面活性剂%呼吸窘迫综合征%并发症%婴儿%新生儿
肺錶麵活性劑%呼吸窘迫綜閤徵%併髮癥%嬰兒%新生兒
폐표면활성제%호흡군박종합정%병발증%영인%신생인
Pulmonary surfactant%Respiratory distress syndrome%Complication%Newborn Infant
目的 对新生儿肺表面活性物质(PS)替代疗法常见并发症的临床特点、诊断及其防治措施进行探讨.方法 对我院新生儿科重症监护病房(NICU)应用PS替代疗法的65例早产儿临床资料进行回顾性分析,分析PS替代治疗常见并发症的发生情况、临床特点、诊断、防治措施及其预后.结果 在65例应用PS的早产儿中,32例发生1～5种并发症,共60例次,其中肺炎14例(21.5%),肺出血10例(15.4%),呼吸暂停、脑室内出血(IVH)及支气管肺发育不良(BPD)各8例(12.3%),动脉导管未闭6例(9.2%),肺不张及早产儿视网膜病(ROP)各3例(4.6%).32例极低出生体重儿中,18例发生不同程度并发症(占56.3%):8例超低出生体重儿中,6例出现并发症(占75.0%).经综合治疗存活54例,存活率为83.1%.死亡11例,病死率为16.9%.结论 正确应用PS,密切监护病情变化,积极预防、早期发现和及时处理各种并发症,是提高PS替代治疗的效果,降低早产儿RDS死亡率的重要措施.
目的 對新生兒肺錶麵活性物質(PS)替代療法常見併髮癥的臨床特點、診斷及其防治措施進行探討.方法 對我院新生兒科重癥鑑護病房(NICU)應用PS替代療法的65例早產兒臨床資料進行迴顧性分析,分析PS替代治療常見併髮癥的髮生情況、臨床特點、診斷、防治措施及其預後.結果 在65例應用PS的早產兒中,32例髮生1～5種併髮癥,共60例次,其中肺炎14例(21.5%),肺齣血10例(15.4%),呼吸暫停、腦室內齣血(IVH)及支氣管肺髮育不良(BPD)各8例(12.3%),動脈導管未閉6例(9.2%),肺不張及早產兒視網膜病(ROP)各3例(4.6%).32例極低齣生體重兒中,18例髮生不同程度併髮癥(佔56.3%):8例超低齣生體重兒中,6例齣現併髮癥(佔75.0%).經綜閤治療存活54例,存活率為83.1%.死亡11例,病死率為16.9%.結論 正確應用PS,密切鑑護病情變化,積極預防、早期髮現和及時處理各種併髮癥,是提高PS替代治療的效果,降低早產兒RDS死亡率的重要措施.
목적 대신생인폐표면활성물질(PS)체대요법상견병발증적림상특점、진단급기방치조시진행탐토.방법 대아원신생인과중증감호병방(NICU)응용PS체대요법적65례조산인림상자료진행회고성분석,분석PS체대치료상견병발증적발생정황、림상특점、진단、방치조시급기예후.결과 재65례응용PS적조산인중,32례발생1～5충병발증,공60례차,기중폐염14례(21.5%),폐출혈10례(15.4%),호흡잠정、뇌실내출혈(IVH)급지기관폐발육불량(BPD)각8례(12.3%),동맥도관미폐6례(9.2%),폐불장급조산인시망막병(ROP)각3례(4.6%).32례겁저출생체중인중,18례발생불동정도병발증(점56.3%):8례초저출생체중인중,6례출현병발증(점75.0%).경종합치료존활54례,존활솔위83.1%.사망11례,병사솔위16.9%.결론 정학응용PS,밀절감호병정변화,적겁예방、조기발현화급시처리각충병발증,시제고PS체대치료적효과,강저조산인RDS사망솔적중요조시.
Objective To investigate the clinical characteristic and prophylactic -therapeutic measures of common complications of pulmonary surfactant(PS) replacement therapy in neonates. Methods We analyzed the clinical data of 65 cases preterm neonates treated with PS replacement therapy in neonatal intensive care unit(NICU) of our hospital. Results In 65 cases,32 cases had one to five complications,totally 60 times. Those included 14 times pneumonia (21.5%), 10 times (15.4%)pneumorrhagia, 8times(12.3%) apnoea, intraventricular hemorrhage and bronchopulmonary dysplasia respectively 6 times(9.2%), patent ductus arteriosus, 3 times(4.6%), atelectasis and retinopathy of prematurity respectively 11 times(16.9%). 18 cases Of 32 xtremely low birth weight infants (56.3%) had different degree complications, and as that of 6 cases of 8 very low birth weight infants.54 cases after complex treatment were survival (survival rate 83.1%) and 11 cases died (mortality 16.9%). Conclusion Active precaution and early discovery and treatment all kinds of complications immediately could improve the effect of PS replacement therapy and reduce the mortality of the preterms.
