中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2010年
4期
409-412
,共4页
王媛%韩小友%丁悌%许翊%王全红
王媛%韓小友%丁悌%許翊%王全紅
왕원%한소우%정제%허익%왕전홍
食管肿瘤%父系%母系%Ⅰ级亲属%危险度
食管腫瘤%父繫%母繫%Ⅰ級親屬%危險度
식관종류%부계%모계%Ⅰ급친속%위험도
Esophagus neoplasms%Paternal line%Matriarchal%1st grade relative%Risk factor
目的 对比分析食管癌病例组与对照组血缘亲属食管癌患病风险,并了解食管癌家族中危险亲属人群患病的新线索.方法 采用病例对照研究方法 ,对食管癌病例组及对照组各720例进行逐层分析,以比较两组各血缘亲属父系、母系食管癌患病危险度(OR)的大小及差异.结果 (1)病例组Ⅰ级亲属食管癌患病危险度(1.34%~2.24%)显著高于对照组(0.78%~1.21%)(P<0.01);Ⅰ级亲属中病例组父母亲食管癌患病危险度为6.11%,显著高于对照组父母亲食管癌患病危险度2.97%(P<0O01).(2)以血缘亲属中父系和母系亲属逐层分析可见,病例组父系食管癌患病危险度(0.87%~1.01%)与母系患病危险度(0.50%~0.79%)均显著高于对照组父系食管癌患病危险度(0.53%~0.65%)与母系患病危险度(0.38%~0.47%)(P<0.05).进一步分析显示,病例组父系中男性亲属与母系中女性亲属,即父系中祖父、父亲、叔伯食管癌患病危险度为2.68%与母系中外祖母、母亲、姨的食管癌患病危险度1.91%均显著高于对照组父系中男性亲属食管癌患病危险度1.50%与母系中女性亲属食管癌患病危险度0.92%(P<0.01).结论 山西省食管癌患者血缘亲属发病危险主要是父亲及其兄弟、母亲及其姐妹,其下代患食管癌风险要大.
目的 對比分析食管癌病例組與對照組血緣親屬食管癌患病風險,併瞭解食管癌傢族中危險親屬人群患病的新線索.方法 採用病例對照研究方法 ,對食管癌病例組及對照組各720例進行逐層分析,以比較兩組各血緣親屬父繫、母繫食管癌患病危險度(OR)的大小及差異.結果 (1)病例組Ⅰ級親屬食管癌患病危險度(1.34%~2.24%)顯著高于對照組(0.78%~1.21%)(P<0.01);Ⅰ級親屬中病例組父母親食管癌患病危險度為6.11%,顯著高于對照組父母親食管癌患病危險度2.97%(P<0O01).(2)以血緣親屬中父繫和母繫親屬逐層分析可見,病例組父繫食管癌患病危險度(0.87%~1.01%)與母繫患病危險度(0.50%~0.79%)均顯著高于對照組父繫食管癌患病危險度(0.53%~0.65%)與母繫患病危險度(0.38%~0.47%)(P<0.05).進一步分析顯示,病例組父繫中男性親屬與母繫中女性親屬,即父繫中祖父、父親、叔伯食管癌患病危險度為2.68%與母繫中外祖母、母親、姨的食管癌患病危險度1.91%均顯著高于對照組父繫中男性親屬食管癌患病危險度1.50%與母繫中女性親屬食管癌患病危險度0.92%(P<0.01).結論 山西省食管癌患者血緣親屬髮病危險主要是父親及其兄弟、母親及其姐妹,其下代患食管癌風險要大.
목적 대비분석식관암병례조여대조조혈연친속식관암환병풍험,병료해식관암가족중위험친속인군환병적신선색.방법 채용병례대조연구방법 ,대식관암병례조급대조조각720례진행축층분석,이비교량조각혈연친속부계、모계식관암환병위험도(OR)적대소급차이.결과 (1)병례조Ⅰ급친속식관암환병위험도(1.34%~2.24%)현저고우대조조(0.78%~1.21%)(P<0.01);Ⅰ급친속중병례조부모친식관암환병위험도위6.11%,현저고우대조조부모친식관암환병위험도2.97%(P<0O01).(2)이혈연친속중부계화모계친속축층분석가견,병례조부계식관암환병위험도(0.87%~1.01%)여모계환병위험도(0.50%~0.79%)균현저고우대조조부계식관암환병위험도(0.53%~0.65%)여모계환병위험도(0.38%~0.47%)(P<0.05).진일보분석현시,병례조부계중남성친속여모계중녀성친속,즉부계중조부、부친、숙백식관암환병위험도위2.68%여모계중외조모、모친、이적식관암환병위험도1.91%균현저고우대조조부계중남성친속식관암환병위험도1.50%여모계중녀성친속식관암환병위험도0.92%(P<0.01).결론 산서성식관암환자혈연친속발병위험주요시부친급기형제、모친급기저매,기하대환식관암풍험요대.
Objective In order to provide new clues on the cause of esophagus-cancer through seeking for information among the relatives of esophagus-cancer-patients at high-risk,contrast analysis was carried out to compare the ORs between esophagus-cancer cases and the relatives of the patients.Methods Case-control study was adopted on 720 cases and 720 controls who were kin relatives of the patients.Results (1) Risk of the relatives to the esophagus-cancer-patient group ( 1.34%-2.24% ) was obviously higher than the control group (0.78%-1.21%) (P<0.01).In 1st grade relatives,the risk of parent' s to the esophagus-cancer patients (6.11% ) was obviously higher than the control group (2.97%) (P<0.01 ).(2) According to the cascade analysis to the cases of both paternal and matriarchal,lines,results showed that the risks of both the paternal line (0.87%-1.01%) and the matriarchal line (0.50%-0.79%) in the group of esophagus-cancer cases were all obviously higher than the lines in the control groups (0.53%-0.65%) and (0.38%-0.47%).Data also showed that the risk among the male relatives of paternal line (eg:grandfathers',father' s,uncles' etc.) in the group of cases was 2.68% while the matriarchal (eg:grandmother's,mother' s,aunts' etc.) was 1.91%.Both figures were obviously higher than that in the control group (1.50% and 0.92%,P<0.01 ).Conclusion The risk factor of esophagus cancer of the next generation seemed higher if the father and his brothers or mother and her sisters having had esophagus-cancers.