CAJ | 학술논문

探讨可溶性细胞间黏附分子1( sICAM-1)和透明质酸(HA)能否反映Graves眼病(GO)的疾病活动性.用ELISA方法检测48例GO患者(眼病组)的sICAM-1、HA水平,同时检测30例单纯Graves甲状腺功能亢进患者作为对照组.与对照组相比,眼病组的血清sICAM-1、HA水平明显增高(P＜0.05);且眼病组活动期的血清sICAM-1、HA水平明显高于稳定期(P＜0.05).Pearson相关性分析显示眼病组的血清sICAM-1、HA水平均与眼病活动分数(CAS)呈显著正相关(r=0.53,P＜0.01;r=0.46,P＜0.01),且sICAM-1与HA亦呈正相关(r=0.31,P＜0.05).GO患者外周血sICAM-1、HA水平可作为评价GO活动性的指标.
탐토가용성세포간점부분자1( sICAM-1)화투명질산(HA)능부반영Graves안병(GO)적질병활동성.용ELISA방법검측48례GO환자(안병조)적sICAM-1、HA수평,동시검측30례단순Graves갑상선공능항진환자작위대조조.여대조조상비,안병조적혈청sICAM-1、HA수평명현증고(P＜0.05);차안병조활동기적혈청sICAM-1、HA수평명현고우은정기(P＜0.05).Pearson상관성분석현시안병조적혈청sICAM-1、HA수평균여안병활동분수(CAS)정현저정상관(r=0.53,P＜0.01;r=0.46,P＜0.01),차sICAM-1여HA역정정상관(r=0.31,P＜0.05).GO환자외주혈sICAM-1、HA수평가작위평개GO활동성적지표.
To investigate weather serum soluble intercellular adhesion molecule-1 (sICAM-1) and hyaluronic acid(HA) levels can be used in assessing the disease activity of Graves' ophthalmopathy (GO).Serum levels of sICAM-1 and HA were determined in 48 cases with GO and 30 cases with Graves' disease without GO (CON).Compared with the CON group,the levels of sICAM-1 and HA in GO cases were raised significantly( P＜0.05 ).sICAM-1 and HA levels in the subgroup of patients with active GO were markedly elevated when compared to those with stable GO(P＜0.05 ).Pearson regression analysis showed that elevated levels of slCAM-1 and HA were positively correlated with the Clinical Activity Score ( CAS ) of GO ( r =0.53,P ＜ 0.01 ; r =0.46,P ＜ 0.01 ) ; A significant correlation between sICAM-1 and HA( r=0.31,P＜0.05 ) was noted.The raised serum levels of sICAM-1and HA may serve as two activity markers of GO.