CAJ | 학술논문

研究复合螺旋藻多糖对人结肠癌H329细胞的抑制作用.螺旋藻多糖(PSP)与银杏叶有效成分(GBE)1:1比例复合组、1:2比例复合组和2:1比例复合组对人结肠癌HT29细胞的抑瘤率,高剂量时分别比空白对照组提高68.04%(P<0.01)、59.88%(P<0.01)和58.82%(P<0.01);中剂量时分别比空白组提高47.52%(P<0.01)、51.98%(P<0.01)和40.31%(P<0.01);低剂量时分别比空白对照组提高39.70%(P<0.01)、29.88%(P<0.01)和27.31%(P<0.01).各复合制剂组的抑瘤率都高于相对应剂量的单一成分组,PSP与GBE联合使用对抑制人结肠癌HT29细胞能产生协同增效作用.
연구복합라선조다당대인결장암H329세포적억제작용.라선조다당(PSP)여은행협유효성분(GBE)1:1비례복합조、1:2비례복합조화2:1비례복합조대인결장암HT29세포적억류솔,고제량시분별비공백대조조제고68.04%(P<0.01)、59.88%(P<0.01)화58.82%(P<0.01);중제량시분별비공백조제고47.52%(P<0.01)、51.98%(P<0.01)화40.31%(P<0.01);저제량시분별비공백대조조제고39.70%(P<0.01)、29.88%(P<0.01)화27.31%(P<0.01).각복합제제조적억류솔도고우상대응제량적단일성분조,PSP여GBE연합사용대억제인결장암HT29세포능산생협동증효작용.
To study the characteristics of compound PSP on Human colon tumor cell strain (HT29) in vitro. The results showed as follows :mixed Polysaccharides of Spirulina platensis(PSP) with active ingredients of Ginkgo biloba L. (GBE) at ratios of 1 : 1,1 : 2 and 2: 1. Compared with the control group, antitumor rates of the high-dose groups at the ratio of 1:1,1 : 2 and 2:1 was respectively enhanced by 68.04% (P < 0.01) ,59.88% (P < 0.01) and 58.82% (P < 0.01) ;antitumor rates of the mid-dose groups was respectively enhanced by 47.52% (P < 0. 01), 51.98% (P < 0. 01) and 40. 31% (P < 0.01) ; antitumor rates of the low-dose groups was respectively enhanced by 39.70% (P < 0.01), 29. 88% (P < 0.01) and 27.31% (P < 0. 01). All of the experimental composite groups showed higher antitumor rates than the corresponding single component groups. The composition of PSP and GBE could cause synergies in multiplica-tion inhibition of HT29 cells.