中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2008年
5期
412-414
,共3页
肝炎%肠道屏障%IgA%分泌片%ZO-1%Occludin
肝炎%腸道屏障%IgA%分泌片%ZO-1%Occludin
간염%장도병장%IgA%분비편%ZO-1%Occludin
Hepatitis%Barrier of gut%IgA%secretory component%ZO-1%Occludin
目的 研究重症肝炎患者肠道IgA、分泌片(SC)和ZO-1、occludin的变化,了解重症肝炎患者伴发腹部症状的原因.方法 采用免疫组化方法分别检测肠道IgA、SC和ZO-1、occludin.结果 与对照组比较,重症肝炎患者肠道IgA、SC和ZO-1、occludin染色明显减弱.结论 重症肝炎患者肠道IgA、SC和ZO-1、occludin表达下降,导致肠道屏障功能发生异常是引起腹部症状的原由之一.
目的 研究重癥肝炎患者腸道IgA、分泌片(SC)和ZO-1、occludin的變化,瞭解重癥肝炎患者伴髮腹部癥狀的原因.方法 採用免疫組化方法分彆檢測腸道IgA、SC和ZO-1、occludin.結果 與對照組比較,重癥肝炎患者腸道IgA、SC和ZO-1、occludin染色明顯減弱.結論 重癥肝炎患者腸道IgA、SC和ZO-1、occludin錶達下降,導緻腸道屏障功能髮生異常是引起腹部癥狀的原由之一.
목적 연구중증간염환자장도IgA、분비편(SC)화ZO-1、occludin적변화,료해중증간염환자반발복부증상적원인.방법 채용면역조화방법분별검측장도IgA、SC화ZO-1、occludin.결과 여대조조비교,중증간염환자장도IgA、SC화ZO-1、occludin염색명현감약.결론 중증간염환자장도IgA、SC화ZO-1、occludin표체하강,도치장도병장공능발생이상시인기복부증상적원유지일.
Objective To study the changes of IgA,secretory component(SC)and ZO-1,occludin of gut in severe hepatitis and to understand the reason of abdomen symptom in severe hepatitis patients.Methods IgA,SC,ZO-1 and occludin of gut were assayed by immunohistochemistry.Results Compared with the controls,the staining of IgA,SC,ZO-1 and occludin in severe hepatitis were notably decreased.Conclusion In severe hepatitis,IgA,SC,ZO-1 and occludin expression of gut decrease,leading to the abnormality of barrier of gut,which is one the reasons of resuhings in abdomen symptoms in severe hepatitis.
