CAJ | 학술논문

目的探讨冠心病(CHD)患者特质焦虑与载脂蛋白E(ApoE)基因ε4等位基因的相关性.方法对符合诊断标准的107例冠心病患者进行焦虑状态-特质问卷(STAI)评定,以特质焦虑评分＞55分为判定高低特质焦虑的标准,分为高特质焦虑组(n=39)和低特质焦虑组(n=68),同时选择50例健康人群作对照(对照组).以Hhal限制性内切酶酶切及琼脂糖凝胶电泳确定ApoE基因多态性.相关分析和回归方法进行统计分析.结果 ApoE基因的等位基因ε4与冠心病患者特质焦虑成显著相关(OR=9.251,95％CI 2.726～18.266).以等位基因ε2、ε3、ε4频率为自变量,特质焦虑评分为因变量进行逐步多元线性回归分析,等位基因ε4进入方程,Y =30.252 +0.048X3(P＜0.05).结论冠心病患者的特质焦虑情绪与ApoE基因ε4等位基因具有相关性.
목적 탐토관심병(CHD)환자특질초필여재지단백E(ApoE)기인ε4등위기인적상관성.방법대부합진단표준적107례관심병환자진행초필상태-특질문권(STAI)평정,이특질초필평분＞55분위판정고저특질초필적표준,분위고특질초필조(n=39)화저특질초필조(n=68),동시선택50례건강인군작대조(대조조).이Hhal한제성내절매매절급경지당응효전영학정ApoE기인다태성.상관분석화회귀방법진행통계분석.결과 ApoE기인적등위기인ε4여관심병환자특질초필성현저상관(OR=9.251,95％CI 2.726～18.266).이등위기인ε2、ε3、ε4빈솔위자변량,특질초필평분위인변량진행축보다원선성회귀분석,등위기인ε4진입방정,Y =30.252 +0.048X3(P＜0.05).결론 관심병환자적특질초필정서여ApoE기인ε4등위기인구유상관성.
Objective To further investigate the relationship between apolipoprotein E(APOE) genotype and trait anxiety in patients with coronary heart disease (CHD).Methods Use the state-trait anxiety inventory (STAI) to investigate the state anxiety and trait anxiety of 107 CHD patients.According the score of TAI,the CHD patients were divided into CHD with high trait anxiety group ( n=39)and low trait anxiety group(n=68).The genotypes and alleles of apolipoprotein E gene was detected in all CHD patients and 50 healthy control subjects with the polymerase reaction(PCR) and restriction fragment length polymorphisms(RFLP) technique.Correlation analysis and logistic regression analysis were used.Results Apolipoprotein E gene showed positive relationship with trait anxiety score( OR =9.251,95％ CI2.726 ～ 18.266).F4 allele entered the regression equaltion Y =30.252 + 0.048X3 (P ＜ 0.05 ).Conclusion The results suggest the polymorphisms of Apolipoprotein E e4 allele may be associated with the trait anxiety symptom.