中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2011年
10期
1094-1096
,共3页
聚己内酯%巩膜外垫压%可吸收性材料
聚己內酯%鞏膜外墊壓%可吸收性材料
취기내지%공막외점압%가흡수성재료
Polycaprolactone (PCL)%Scleral buckle%Absorbable materials
目的 探讨聚己内酯作为可吸收性巩膜外垫压材料的可行性.方法 将24只青紫兰兔随机分为4组,左眼为实验眼,将聚己内酯固定于巩膜壁行常规巩膜外垫压术；右眼为对照眼植入硅胶海绵.A、B、C、D4组分别于术后4周、8周、12周、16周行眼部B超检查,测量巩膜嵴高度；行大体标本和组织切片检查,观察植入后炎症反应情况.采用重量、分子量指标观察聚己内酯植入后4周、8周、12周、16周的降解情况.结果 术后无一例发生植入物感染或脱出现象.聚己内酯外垫压材料在实验阶段内维持足够的巩膜嵴高度,平均约2.2 mm.植入物周围炎症反应与硅胶海绵相近,且炎症反应不因聚己内酯降解而加剧.聚己内酯在实验阶段内仅分子量下降,而重量无明显改变.结论 聚己内酯作为可吸收性巩膜外垫压材料效果确切、安全可靠,有可能成为一种新型的的可吸收性材料应用于临床.
目的 探討聚己內酯作為可吸收性鞏膜外墊壓材料的可行性.方法 將24隻青紫蘭兔隨機分為4組,左眼為實驗眼,將聚己內酯固定于鞏膜壁行常規鞏膜外墊壓術；右眼為對照眼植入硅膠海綿.A、B、C、D4組分彆于術後4週、8週、12週、16週行眼部B超檢查,測量鞏膜嵴高度；行大體標本和組織切片檢查,觀察植入後炎癥反應情況.採用重量、分子量指標觀察聚己內酯植入後4週、8週、12週、16週的降解情況.結果 術後無一例髮生植入物感染或脫齣現象.聚己內酯外墊壓材料在實驗階段內維持足夠的鞏膜嵴高度,平均約2.2 mm.植入物週圍炎癥反應與硅膠海綿相近,且炎癥反應不因聚己內酯降解而加劇.聚己內酯在實驗階段內僅分子量下降,而重量無明顯改變.結論 聚己內酯作為可吸收性鞏膜外墊壓材料效果確切、安全可靠,有可能成為一種新型的的可吸收性材料應用于臨床.
목적 탐토취기내지작위가흡수성공막외점압재료적가행성.방법 장24지청자란토수궤분위4조,좌안위실험안,장취기내지고정우공막벽행상규공막외점압술；우안위대조안식입규효해면.A、B、C、D4조분별우술후4주、8주、12주、16주행안부B초검사,측량공막척고도；행대체표본화조직절편검사,관찰식입후염증반응정황.채용중량、분자량지표관찰취기내지식입후4주、8주、12주、16주적강해정황.결과 술후무일례발생식입물감염혹탈출현상.취기내지외점압재료재실험계단내유지족구적공막척고도,평균약2.2 mm.식입물주위염증반응여규효해면상근,차염증반응불인취기내지강해이가극.취기내지재실험계단내부분자량하강,이중량무명현개변.결론 취기내지작위가흡수성공막외점압재료효과학절、안전가고,유가능성위일충신형적적가흡수성재료응용우림상.
Objective To evaluate the feasibility of polycaprolactone (PCL) used for scleral buckling implants.Methods Twenty-four healthy pigmented rabbits were chosen and divided into 4groups.The left eye of each group had PCL implants; the right eye had silicon sponge as control.The buckle heights created by implants were measured with B-scan and the eyeballs were enucleated for macroscopic and histopathological examinations to evaluate the tissue reactions 4 weeks,8 weeks,12 weeks and 16 weeks after surgery respectively.Weight lose,molecular weight were measured to observe the biodegradation of PCL.Results There were no complications,such as secondary infection or extrusion after operation.The buckle height created by PCL lasted for the whole follow-up period of 16 weeks.Compared with silicon sponge,tissue reactions of PCL implants were mild; the reaction did not increase in the study.The weight lose of PCL had no obvious changes; the molecular weight had decreased during the study.Conclusions PCL is effective and safe in the treatment of retinal detachment as absorbable scleral buckling materials,may be used as a new scleral buckle in the future.
