CAJ | 학술논문

目的探讨家族性腺瘤性息肉病(familial adenomatous polyposis,FAP)患者伴发上消化道息肉(胃及十二指肠)的发生率、内镜下的表现特征及其病理学特点.方法对上海第二军医大学长海医院2004年1月至2010年6月收治的57例临床诊断为FAP患者采用胃镜、十二指肠侧视镜进行上消化道病变的筛查,并对发现的息肉样病灶进行组织学活检,分析FAP伴胃及十二指肠息肉的发病状况.结果本组57例FAP患者中发生胃内息肉38例,占67％,息肉多数位于胃体和胃窦部,为增生性息肉；十二指肠息肉12例,占21％,其中7例为腺瘤性息肉.结论上消化道息肉是FAP最常见的大肠外病变,胃内息肉多为增生性息肉；而十二指肠可能伴发腺瘤性息肉,属癌前病变.
목적 탐토가족성선류성식육병(familial adenomatous polyposis,FAP)환자반발상소화도식육(위급십이지장)적발생솔、내경하적표현특정급기병이학특점.방법 대상해제이군의대학장해의원2004년1월지2010년6월수치적57례림상진단위FAP환자채용위경、십이지장측시경진행상소화도병변적사사,병대발현적식육양병조진행조직학활검,분석FAP반위급십이지장식육적발병상황.결과 본조57례FAP환자중발생위내식육38례,점67％,식육다수위우위체화위두부,위증생성식육；십이지장식육12례,점21％,기중7례위선류성식육.결론 상소화도식육시FAP최상견적대장외병변,위내식육다위증생성식육；이십이지장가능반발선류성식육,속암전병변.
Objective To discuss the incidence,endoscopic manifestion and pathological features of the upper-gastrointestinal polyps ( stomach and deodenum) in FAP patients. Methods During 2004 -2010 a total 57 FAP patients at Changhai Hospital underwent screening for polyps in upper-gastrointestinal tract by gastroscopy and sideward-viewing duodenoscopy. Biopsies were taken on the polypoid lesions.Results Gastric polyps were found in 38 patients (67％).Most polyps were located at gastric body and antrum,the pathologic diagnosis was hyperplastic. Duodenal polyps were found in 12 patients (21％) including 7 cases of adenomatous polys. Conclusions Upper- gastrointestinal polyps are the most common extra-colonic manifestion in FAP. Most stomach polyps are located at gastric body and antrum and are hyperplastic.Polyps at duodenum may be adenomatous,which is a precusor of carcinoma.