CAJ | 학술논문

酒石酸卡巴拉汀是一种乙酰胆碱酯酶抑制剂，用于治疗中、轻度老年痴呆症（即阿尔茨海默氏症：AD），目前已在瑞士上市，市场前景看好。该文研究了一条适合国内生产的合成路线，先合成外消旋体，再和D-酒石酸衍生物形成非对映体盐，通过分级结晶进行分离，获得S-异构体。
주석산잡파랍정시일충을선담감지매억제제，용우치료중、경도노년치태증（즉아이자해묵씨증：AD），목전이재서사상시，시장전경간호。해문연구료일조괄합국내생산적합성로선，선합성외소선체，재화D-주석산연생물형성비대영체염，통과분급결정진행분리，획득S-이구체。
Rivastigmine, a sort of acetylcholinesterase inhibitor, is usedin the symptomatic treatment of mild to moderate Alzheimer's Disease (AD). Now it has been launched in Switzerland, and the market prospect is very good. In this essa y, we have studied a synthesis routine of Rivastigmine, which is suitable of dom estic production. We prepared the racemic and gained (S)-isomer by the resoluti on with D-DTTA.