CAJ | 학술논문

HIV-1感染早期的生物学特征及免疫学应答可能是决定艾滋病病程的一个重要因素.近来有研究发现初始有效的免疫应答可驱动病毒逃逸突变的产生,这使得人们对抵御病毒传播的早期免疫应答和急性期病毒血症的控制有了进一步的认识.强烈的固有免疫应答和获得性免疫应答在感染后即可发生,但对于清除病毒却为时已晚.此文讨论了近年来关于HIV-I感染早期免疫应答动力学和特征方面的研究及其对研制有效预防性疫苗的意义.
HIV-1감염조기적생물학특정급면역학응답가능시결정애자병병정적일개중요인소.근래유연구발현초시유효적면역응답가구동병독도일돌변적산생,저사득인문대저어병독전파적조기면역응답화급성기병독혈증적공제유료진일보적인식.강렬적고유면역응답화획득성면역응답재감염후즉가발생,단대우청제병독각위시이만.차문토론료근년래관우HIV-I감염조기면역응답동역학화특정방면적연구급기대연제유효예방성역묘적의의.
The early immune response to HIV-1 infection is likely to be an important factor in determining the clinical course of disease. Recently, the finding that the first effective immune responses drive the selection of virus escape mutations provides insight into the earliest immune responses against the transmitted virus and their contributions to the control of acute viraemia. Strong innate and adaptive immune responses occur subsequently, but they are too late to eliminate the infection. Recent studies on the kinetics and quality of early immune responses to HIV-1 and their implications for developing a successful preventive HIV-1 vaccine are reviewed in this article.