中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
35期
5-7
,共3页
王俊丽%尹林林%李静%张钢峰%张晓雁%马加斌%张运贵
王俊麗%尹林林%李靜%張鋼峰%張曉雁%馬加斌%張運貴
왕준려%윤림림%리정%장강봉%장효안%마가빈%장운귀
胃肿瘤%癌前状态%癌胚抗原%抗肿瘤联合化疗方案
胃腫瘤%癌前狀態%癌胚抗原%抗腫瘤聯閤化療方案
위종류%암전상태%암배항원%항종류연합화료방안
Stomach neoplasms%Precancerous conditions%Carcinoembryonic antigen%Anti-neoplastic combined chemotherapy protocols
目的 观察化疗药物对异位肿瘤合并癌前病变者胃组织匀浆中癌胚抗原(CEA)表达的影响.方法 45例肿瘤患者(癌前病变组)化疗前经胃镜检查均有不典型增生或肠上皮化生.在化疗前及化疗6个周期后分别行胃镜检查,在同一部位取胃组织,测定胃组织匀浆中CEA的表达.取10例肿瘤患者正常胃黏膜组织作为对照组.分别比较对照组和癌前病变组、癌前病变组治疗前后胃组织匀浆中CEA的表达.结果 癌前病变组、对照组胃组织匀浆中CEA分别为(27.76±9.67)、(3.32±0.60)μg/L,两组比较差异有统计学意义(P<0.05).癌前病变组治疗前后胃组织匀浆中CEA分别为(27.76±9.67)、(26.60±10.80)μg/L,两者比较差异有统计学意义(P<0.05).轻中度不典型增生、轻中度肠上皮化生胃组织匀浆中治疗前CEA分别为(23.11±4.11)、(17.10±1.66)μg/L,治疗后CEA分别为(21.11±5.66)、(15.10±3.31)μg/L,轻中度癌前病变治疗前后比较差异有统计学意义(P<0.05),重度癌前病变治疗前后比较差异无统计学意义.结论 化疗药物可明显降低轻中度癌前病变胃组织匀浆中CEA的表达,提示轻中度癌前病变有逆转可能.
目的 觀察化療藥物對異位腫瘤閤併癌前病變者胃組織勻漿中癌胚抗原(CEA)錶達的影響.方法 45例腫瘤患者(癌前病變組)化療前經胃鏡檢查均有不典型增生或腸上皮化生.在化療前及化療6箇週期後分彆行胃鏡檢查,在同一部位取胃組織,測定胃組織勻漿中CEA的錶達.取10例腫瘤患者正常胃黏膜組織作為對照組.分彆比較對照組和癌前病變組、癌前病變組治療前後胃組織勻漿中CEA的錶達.結果 癌前病變組、對照組胃組織勻漿中CEA分彆為(27.76±9.67)、(3.32±0.60)μg/L,兩組比較差異有統計學意義(P<0.05).癌前病變組治療前後胃組織勻漿中CEA分彆為(27.76±9.67)、(26.60±10.80)μg/L,兩者比較差異有統計學意義(P<0.05).輕中度不典型增生、輕中度腸上皮化生胃組織勻漿中治療前CEA分彆為(23.11±4.11)、(17.10±1.66)μg/L,治療後CEA分彆為(21.11±5.66)、(15.10±3.31)μg/L,輕中度癌前病變治療前後比較差異有統計學意義(P<0.05),重度癌前病變治療前後比較差異無統計學意義.結論 化療藥物可明顯降低輕中度癌前病變胃組織勻漿中CEA的錶達,提示輕中度癌前病變有逆轉可能.
목적 관찰화료약물대이위종류합병암전병변자위조직균장중암배항원(CEA)표체적영향.방법 45례종류환자(암전병변조)화료전경위경검사균유불전형증생혹장상피화생.재화료전급화료6개주기후분별행위경검사,재동일부위취위조직,측정위조직균장중CEA적표체.취10례종류환자정상위점막조직작위대조조.분별비교대조조화암전병변조、암전병변조치료전후위조직균장중CEA적표체.결과 암전병변조、대조조위조직균장중CEA분별위(27.76±9.67)、(3.32±0.60)μg/L,량조비교차이유통계학의의(P<0.05).암전병변조치료전후위조직균장중CEA분별위(27.76±9.67)、(26.60±10.80)μg/L,량자비교차이유통계학의의(P<0.05).경중도불전형증생、경중도장상피화생위조직균장중치료전CEA분별위(23.11±4.11)、(17.10±1.66)μg/L,치료후CEA분별위(21.11±5.66)、(15.10±3.31)μg/L,경중도암전병변치료전후비교차이유통계학의의(P<0.05),중도암전병변치료전후비교차이무통계학의의.결론 화료약물가명현강저경중도암전병변위조직균장중CEA적표체,제시경중도암전병변유역전가능.
Objective To investigate the effect of chemotherapy drugs on the expression of carci-noembryonic antigen (CEA) in the gastric tissue with precancerous lesions in ectopie cancer. Methods There were 45 cases of cancer patients (precancerous lesions group), the pathological biopsy showed that there were atypical hyperplasia or intestinal metaplasia by gastroscope before chemotherapy. Gastruscope was done before chemotherapy and after six cycles of chemotherapy. Gastric tissue was taken respectively in the same site. The expression of CEA was measured in the gastric tissue. Normal gastric tissue taken from 10 cases of cancer patients was served as control. Compared respectively the expression of CEA in the gastric tissue in control group and precancerous lesions group, in precancerous lesions group between before and after treatment. Results CEA expression in the gastric tissue was (27.76±9.67), (3.32±0.60)μg/L in precancerous lesions group and control group respectively, there was significant difference between two groups(P<0.05). CEA expression in the gastric tissue was (27.76±9.67), (26.60±10.80)μg/L before and after treatment in precancerous lesions group respectively, P<0.05. CEA expression in the gastric tissue before treatment was (23.11±4.11), (17.10±1.66)μg/L, after treatment was (21.11±5.66), (15.10±3.31)μg/L in the mild to moderate atypical hyperplasia, mild to moderate intestinal metaplasia respectively, there was significant difference between before and after treatment in the mild to moderate precancerous lesions. There was no significant difference between before and after treatment in the severe precancerous lesions. Conclusions Chemotherapy drugs can significantly reduce the expression of CEA in the gastric tis-sue in the mild to moderate precancerous lesions. The results suggests that mild to moderate precancerous lesions can be reversed.