CAJ | 학술논문

目的探讨血清内脂素水平与冠心病的关系.方法 88例住院患者,根据冠状动脉造影的结果分为冠心病组(62例)及对照组(26例),其中冠心病组分为单支病变组、双支病变组、多支病变组,采用ELISA法测定内脂素.同时记录冠心病患者Gensini冠脉病变积分,并与血清内脂素进行相关性分析.结果冠心病组患者血清内脂素明显高于对照组[(10.77±2.63)μg/L与(7.13±2.06)μg/L,t=-6.283,P＜0.01].内脂素随冠状动脉病变支数的增加而升高(P＜0.05).冠状动脉造影正常、单支病变、双支病变、多支病变的患者,其血清中内脂素水平分别为(7.13±2.06)、(9.30±2.19)、(10.81±2.12)、(12.79±2.20)μg/L.血清内脂素与Gensini冠脉病变积分呈显著正相关(r=0.483,P＜0.01).结论内脂素升高与冠心病密切相关,内脂素浓度越高,冠状动脉病变越严重.
목적 탐토혈청내지소수평여관심병적관계.방법 88례주원환자,근거관상동맥조영적결과분위관심병조(62례)급대조조(26례),기중관심병조분위단지병변조、쌍지병변조、다지병변조,채용ELISA법측정내지소.동시기록관심병환자Gensini관맥병변적분,병여혈청내지소진행상관성분석.결과 관심병조환자혈청내지소명현고우대조조[(10.77±2.63)μg/L여(7.13±2.06)μg/L,t=-6.283,P＜0.01].내지소수관상동맥병변지수적증가이승고(P＜0.05).관상동맥조영정상、단지병변、쌍지병변、다지병변적환자,기혈청중내지소수평분별위(7.13±2.06)、(9.30±2.19)、(10.81±2.12)、(12.79±2.20)μg/L.혈청내지소여Gensini관맥병변적분정현저정상관(r=0.483,P＜0.01).결론 내지소승고여관심병밀절상관,내지소농도월고,관상동맥병변월엄중.
Objective To study the relationship of serum visfatin level and coronary heart disease (CHD). Methods Eighty eight hospitalized patients were enrolled into the study and divided into CHD group(n = 62) and non-CHD control group(n = 26) according to the angiography results; the CHD group was further divided into single-, double-, multi-vessel affected groups. The serum level of visfatin was measured by ELISA,the lesion severity of coronary arteries was assessed by Gensini coronary scoring system, and the correlation between serum visfatin level and coronary lesion severity was evaluated statistically. Results The level of serum visfatin was significantly higher in CHD group than the control group([ 10. 77 ± 2. 63 ] μg/L vs. [ 7. 13 ± 2. 06 ]μg/L,P ＜ 0. 05). The visfatin level increased along with the the number of stenosis vessels(P ＜ 0. 05). The sermn visfatin levels of no stenosis, single-, double-, multi-vessel groups were(7. 13 ± 2. 06) μg/L,(9. 30±2. 19) μg/L,(10. 81 ± 2. 12) μg/L,(12. 79 ± 2. 20) μg/L respectively. A significant positive correlation was found between coronary lesion severity score and serum visfatin level(r = 0. 483, P ＜ 0. 01). Conclusion The visfatin may be directly related to the initiation and development of coronary diseases. The higher level of serum visfatin was, the more severe coronary artery disease would be.