肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
3期
182-185
,共4页
张红云%兰胜民%曹建忠%王宏卫%任淑惠%鲁萍%郭修栋
張紅雲%蘭勝民%曹建忠%王宏衛%任淑惠%魯萍%郭脩棟
장홍운%란성민%조건충%왕굉위%임숙혜%로평%곽수동
癌,非小细胞肺%放射疗法,适形%预后%因素分析,统计学
癌,非小細胞肺%放射療法,適形%預後%因素分析,統計學
암,비소세포폐%방사요법,괄형%예후%인소분석,통계학
Carcinoma,non-small-cell lung%Radiotherapy,conformal%Prognosis%Factor analysis,statistical
目的 分析早期非小细胞肺癌( NSCLC)放射治疗的疗效及预后影响因素.方法 收集不能或不愿手术的早期NSCLC患者81例.其中鳞状细胞癌60例,腺癌16例,腺鳞癌及未分型癌5例.常规放疗45例,三维适形放疗36例；剂量为50 ～ 96 Gy.Kaplan-Meier法和Log-rank法比较生存率,Cox回归分析法进行多因素分析.结果 全组中位生存时间34个月,总1、3、5年生存率分别为88.7％、41.9％、21.8％.单因素分析显示:不同Karnofsky评分(x2=19.56,P=0.000)、临床分期(x2=8.83,P=0.003)、肿瘤直径(x2=8.13,P=0.004)、近期疗效(x2=14.87,P=0.000)对生存影响差异有统计学意义.多因素回归分析显示放射治疗前Karnofsky评分(x2=11.27,P=0.001)和肿瘤直径(x2=4.89,P=0.027)是影响早期NSCLC患者预后的独立因素.结论 放射治疗前Karnofsky评分、肿瘤直径对早期NSCLC患者放射治疗的预后可能产生明显影响.
目的 分析早期非小細胞肺癌( NSCLC)放射治療的療效及預後影響因素.方法 收集不能或不願手術的早期NSCLC患者81例.其中鱗狀細胞癌60例,腺癌16例,腺鱗癌及未分型癌5例.常規放療45例,三維適形放療36例；劑量為50 ～ 96 Gy.Kaplan-Meier法和Log-rank法比較生存率,Cox迴歸分析法進行多因素分析.結果 全組中位生存時間34箇月,總1、3、5年生存率分彆為88.7％、41.9％、21.8％.單因素分析顯示:不同Karnofsky評分(x2=19.56,P=0.000)、臨床分期(x2=8.83,P=0.003)、腫瘤直徑(x2=8.13,P=0.004)、近期療效(x2=14.87,P=0.000)對生存影響差異有統計學意義.多因素迴歸分析顯示放射治療前Karnofsky評分(x2=11.27,P=0.001)和腫瘤直徑(x2=4.89,P=0.027)是影響早期NSCLC患者預後的獨立因素.結論 放射治療前Karnofsky評分、腫瘤直徑對早期NSCLC患者放射治療的預後可能產生明顯影響.
목적 분석조기비소세포폐암( NSCLC)방사치료적료효급예후영향인소.방법 수집불능혹불원수술적조기NSCLC환자81례.기중린상세포암60례,선암16례,선린암급미분형암5례.상규방료45례,삼유괄형방료36례；제량위50 ～ 96 Gy.Kaplan-Meier법화Log-rank법비교생존솔,Cox회귀분석법진행다인소분석.결과 전조중위생존시간34개월,총1、3、5년생존솔분별위88.7％、41.9％、21.8％.단인소분석현시:불동Karnofsky평분(x2=19.56,P=0.000)、림상분기(x2=8.83,P=0.003)、종류직경(x2=8.13,P=0.004)、근기료효(x2=14.87,P=0.000)대생존영향차이유통계학의의.다인소회귀분석현시방사치료전Karnofsky평분(x2=11.27,P=0.001)화종류직경(x2=4.89,P=0.027)시영향조기NSCLC환자예후적독립인소.결론 방사치료전Karnofsky평분、종류직경대조기NSCLC환자방사치료적예후가능산생명현영향.
Objective To evaluate the prognosis influencing factors of early non-small cell luny cancer (NSCLC) after radiotherapy.Methods 81 early NSCLC patients received definitive radiotherapy and were eligible.Among these patients,60 were diagnosed as squamous cell carcinoma,16 were adenocarcinoma and 5 were diagnosed through imaging instead of pathology.45 patients received conventional radiotherapy,36 patients received three dimensional conformal radiotherapy (3D-CRT),All of them received a total dose of 50-96 Gy with a median dose of 67.8 Gy. Kaplan-Meier survival curves and Cox regression model analysis were applied to evaluate the survival and prognostic factors. Results The median survival time was 34 months.The 1-,3- and 5-year survival rates (OS) were 88.7 ％,41.9 ％,21.8 ％,respectively.Karnofsky performance status≥80,Clinical stage, diameter≤4 cm and the therapeutic effect were associated with improving overall survival.Cox hazards model showed that Karnofsky performance status≥ 80 and diameter≤4 cm were likely to be independent positive prognostic factors. Conclusion Karnofsky performance status and tumor diamater can be used to evaluate the prognosis of early NSCLC after radiotherapy.
