CAJ | 학술논문

[目的]观察不同剂量柚皮苷对腰5脊神经结扎加切断(L5 SNL)引起的神经病理性疼痛的抑制作用.[方法]利用行为学测试的方法,我们检测了口服柚皮苷对L5 SNL大鼠50%机械刺激撤足阈值的影响.[结果]30,90,100 mg/kg柚皮苷可显著提高L5 SNL大鼠的50%机械刺激撤足阈值,10 mg/kg无效.单次给药(30或90 mg/kg)对大鼠50%机械刺激撤足阈值缓解作用可达6 h左右,连续7天给予柚皮苷(30 mg/kg,每天1次)其作用可持续至停药后4 d.[结论]口服柚皮苷可缓解外周神经损伤引起的神经病理性疼痛.
[목적]관찰불동제량유피감대요5척신경결찰가절단(L5 SNL)인기적신경병이성동통적억제작용.[방법]이용행위학측시적방법,아문검측료구복유피감대L5 SNL대서50%궤계자격철족역치적영향.[결과]30,90,100 mg/kg유피감가현저제고L5 SNL대서적50%궤계자격철족역치,10 mg/kg무효.단차급약(30혹90 mg/kg)대대서50%궤계자격철족역치완해작용가체6 h좌우,련속7천급여유피감(30 mg/kg,매천1차)기작용가지속지정약후4 d.[결론]구복유피감가완해외주신경손상인기적신경병이성동통.
[Objective] To investigate the effect of naringin at different doses on the neuropathie pain produced by lumbar 5 spinal nerve ligafion (L5 SNL). [Methods] Using the method of behavioral test, we tested the 50% paw withdrawal threshold before and after intragastrieal application of naringin in the rats with L5 SNL. [Results] Naringin at 30, 90, 100 mg/kg but not at 10 mg/kg increased the 50% paw withdrawal threshold of 1.5 SNL rats significantly. Single application of Naringin (at 30 or 90 mg/kg) inhibited mechanical allodynia for around 6 hours, and the inhibitory effect persisted for 4 days after the cessation of the drug when naringin (30 mg/kg, daily) was consecutively applied for 7 days. [Conclusion] Intragastrical of naringin could relieve the neuropathic pain produced by peripheral nerve injury.